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Tolamolol
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Catalog No. T68164Cas No. 38103-61-6
Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias.
Tolamolol
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Purity: 98.59%
Catalog No. T68164Cas No. 38103-61-6
Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $105 | In Stock | In Stock | |
| 5 mg | $200 | In Stock | In Stock | |
| 10 mg | $280 | In Stock | In Stock | |
| 25 mg | $506 | In Stock | In Stock | |
| 50 mg | $660 | In Stock | In Stock | |
| 100 mg | $980 | - | In Stock | |
| 500 mg | $1,960 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.59%
Appearance:Solid
Color:White
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Product Introduction
Tolamolol AI Summary
Tolamolol exhibits comprehensive pharmacokinetic and physicochemical properties, with a volume of distribution (Vdss) of 3.2 to 4.0 L/kg and an unbound fraction in plasma (Fu) of 0.09, signifying its distribution and free drug level. The compound’s ionization constant (pKa) is 7.9, indicating its ionization behavior. Pharmacokinetically, it has a moderate clearance rate of 14.0 mL/min/kg and a half-life of 2.5 hours, with a mean residence time of 4.8 hours. Tolamolol demonstrates bioactivity, including a potency of 454.8 nM in the S16 Schwann cell viability assay, and significant in vivo inhibition of beta-1 (ED50 of 0.133 mg/kg) and beta-2 adrenergic receptors (81% inhibition of vasodepressor response) in anesthetized cats. Additionally, the compound shows antiviral properties, inhibiting SARS-CoV-2-induced cytotoxicity in VERO-6 and Caco-2 cells at 10 µM, with an IC50 value greater than 19952.62 nM, and shows activity against the SARS-CoV-2 3CL-Pro protease. Moreover, Tolamolol displays minimal inhibitory effects on human HDAC6 enzyme activity, reflecting a nuanced pharmacological profile suitable for further therapeutic exploration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias. |
| Molecular Weight | 344.4 |
| Formula | C19H24N2O4 |
| Cas No. | 38103-61-6 |
| Smiles | O(CC(CNCCOC1=CC=C(C(N)=O)C=C1)O)C2=C(C)C=CC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 18.33 mg/mL (53.22 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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