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MAHMA NONOate

🥰Excellent
Catalog No. T74030Cas No. 146724-86-9

MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.

MAHMA NONOate

MAHMA NONOate

🥰Excellent
Catalog No. T74030Cas No. 146724-86-9
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
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2 mg$30-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:≥98%
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COA HNMR

Product Introduction

Bioactivity
Description
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
In vitro
MAHMA NONOate (0.1 nM - 100 μM) induces concentration-dependent inhibition of collagen or ADP-induced platelet aggregation, but its potency as an aggregation inhibitor is inferior to its potency as a pulmonary vasodilator [1].
In vivo
Intravenous injection of MAHMA NONOate (0.3-10 nmol/kg/min; once) in pentobarbital-anesthetized male Wistar rats led to dose-dependent decreases in mean systemic arterial pressure, proving more effective than GSNO, and also caused dose-dependent inhibition of the response to 0.3 μM/kg ADP[2].
Chemical Properties
Molecular Weight204.27
FormulaC8H20N4O2
Cas No.146724-86-9
SmilesO=NN(O)N(C)CCCCCCNC
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 40 mg/mL (195.82 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.8955 mL24.4774 mL48.9548 mL244.7741 mL
5 mM0.9791 mL4.8955 mL9.7910 mL48.9548 mL
10 mM0.4895 mL2.4477 mL4.8955 mL24.4774 mL
20 mM0.2448 mL1.2239 mL2.4477 mL12.2387 mL
50 mM0.0979 mL0.4895 mL0.9791 mL4.8955 mL
100 mM0.0490 mL0.2448 mL0.4895 mL2.4477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NOSynthaseNO SynthaseEndogenousMetaboliteEndogenous Metabolite
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