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MAHMA NONOate

Name: MAHMA NONOate
Brand: TargetMol
SKU: T74030
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74030Cas No. 146724-86-9

MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.

MAHMA NONOate

😃Good

Catalog No. T74030Cas No. 146724-86-9

MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
In vitro	MAHMA NONOate (0.1 nM - 100 μM) induces concentration-dependent inhibition of collagen or ADP-induced platelet aggregation, but its potency as an aggregation inhibitor is inferior to its potency as a pulmonary vasodilator [1].
In vivo	Intravenous injection of MAHMA NONOate (0.3-10 nmol/kg/min; once) in pentobarbital-anesthetized male Wistar rats led to dose-dependent decreases in mean systemic arterial pressure, proving more effective than GSNO, and also caused dose-dependent inhibition of the response to 0.3 μM/kg ADP[2].

Chemical Properties

Molecular Weight	204.27
Formula	C₈H₂₀N₄O₂
Cas No.	146724-86-9
Smiles	O=NN(O)N(C)CCCCCCNC

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (195.82 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.8955 mL	24.4774 mL	48.9548 mL	244.7741 mL
5 mM	0.9791 mL	4.8955 mL	9.7910 mL	48.9548 mL
10 mM	0.4895 mL	2.4477 mL	4.8955 mL	24.4774 mL
20 mM	0.2448 mL	1.2239 mL	2.4477 mL	12.2387 mL
50 mM	0.0979 mL	0.4895 mL	0.9791 mL	4.8955 mL
100 mM	0.0490 mL	0.2448 mL	0.4895 mL	2.4477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc