DNA-PKcs Protein, Human, Recombinant (GST)

Name: DNA-PKcs Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00205
Rating: 4.5 (1 reviews)

(Synonyms: S473K, PRKDC, p460, HYRC1, HYRC, DNPK1, DNA-PKcs, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit) Copy Product Info

Synonyms: S473K, PRKDC, p460, HYRC1, HYRC, DNPK1, DNA-PKcs, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit

Catalog No. TMPC-00205 Copy Product Info

DNA-PKcs Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P78527.

Pack Size	Price	USA Stock	Global Stock	Quantity
20 µg	$953	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	DNA-PKcs Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P78527.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	P78527
Construction	Recombinant human DNAPK (3746-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, and 25% glycerol.
Synonyms	S473K, PRKDC, p460, HYRC1, HYRC, DNPK1, DNA-PKcs, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit
Research Background	PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a kinase that forms part of a complex (DNA-dependent protein kinase [DNA-PK]) crucial for DNA double-strand break repair and V(D)J recombination. PRKDC expression was significantly increased in breast cancer tissue samples compared with NATs. High PRKDC expression was associated with higher tumor grade (P=0.001), positive lymph node metastasis (P=0.0357) and chemoresistance (P=0.0006). Furthermore, PRKDC expression was significantly correlated with OS in breast cancer patients with (0.0101) or without (P=0.0216) receiving chemotherapy. Collectively, PRKDC is a prognostic biomarker for chemoresistance in breast cancer patients.

Chemical Properties

Molecular Weight

~68 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.