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Diflufenican

Name: Diflufenican
Brand: TargetMol
SKU: T21012
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21012Cas No. 83164-33-4

Alias M&B 38544

Diflufenican (M&B 38544) increases the production of phytoene in carrot cell cultures by inducing the inhibition of phytoene desaturase gene expression.

Diflufenican

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Purity: 99.62%

Catalog No. T21012Alias M&B 38544Cas No. 83164-33-4

Diflufenican (M&B 38544) increases the production of phytoene in carrot cell cultures by inducing the inhibition of phytoene desaturase gene expression.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$50	In Stock	In Stock
5 g	$79	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.62%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Diflufenican AI Summary

Diflufenican exhibits a broad spectrum of bioactivities across various biological targets and applications. It shows inhibitory effects on several molecular targets including Human Jumonji Domain Containing 2E (JMJD2E), Menin-MLL interaction in MLL Related Leukemias, Neuropeptide S Receptor, Polymerase Kappa, and activators of ClpP. Furthermore, it displays antagonistic effects on the gsp mutation associated with Fibrous Dysplasia/McCune-Albright Syndrome and demonstrates activity in cytochrome panel assays targeting p450-cyp2c19 and p450-cyp1a2 enzymes, indicating its potential in diverse pharmacological areas. Additionally, Diflufenican possesses potent herbicidal properties, showing significant inhibition of plant growth and chlorophyll production against species such as Amaranthus retroflexus, Brassica rapa subsp. oleifera, Digitaria adscendens, and Echinochloa crus-galli. It effectively inhibits fresh plant weight under both postemergence and preemergence conditions at various application rates, and demonstrates strong bleaching activity in Spirodela polyrhiza fronds, inhibiting chlorophyll by 90.0% to 94.0% at specific concentrations. Moreover, it displays potent inhibitory activity against colored carotenoid formation in Nicotiana tabacum with an IC50 value of 38.0 nM. Overall, Diflufenican is characterized by its versatile bioactivities and significant potential for pharmacological and agricultural applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diflufenican (M&B 38544) increases the production of phytoene in carrot cell cultures by inducing the inhibition of phytoene desaturase gene expression.
Synonyms	M&B 38544

Chemical Properties

Molecular Weight	394.29
Formula	C₁₉H₁₁F₅N₂O₂
Cas No.	83164-33-4
Smiles	FC1=CC(F)=C(NC(=O)C2=C(OC3=CC=CC(=C3)C(F)(F)F)N=CC=C2)C=C1
Relative Density.	1.4301 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (139.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5362 mL	12.6810 mL	25.3620 mL	126.8102 mL
5 mM	0.5072 mL	2.5362 mL	5.0724 mL	25.3620 mL
10 mM	0.2536 mL	1.2681 mL	2.5362 mL	12.6810 mL
20 mM	0.1268 mL	0.6341 mL	1.2681 mL	6.3405 mL
50 mM	0.0507 mL	0.2536 mL	0.5072 mL	2.5362 mL
100 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc