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Iloprost

Name: Iloprost
Brand: TargetMol
SKU: T15560
Rating: 4.5 (1 reviews)

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Catalog No. T15560Cas No. 78919-13-8

Alias ZK 36374, Ciloprost

Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.

Iloprost

😃Good

Catalog No. T15560Alias ZK 36374, CiloprostCas No. 78919-13-8

Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$246	35 days	35 days
500 μg	$490	35 days	35 days
1 mg	$855	35 days	35 days
5 mg	$3,650	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.
In vitro	Iloprost is a PGI2 analog that affects the maturation and developmental competence of bovine oocytes. 0.5 μM Iloprost treatment for 22-24 hours increased the blastocyst rate and the proportion of expanded blastocysts in bovine embryos, increased the maturation rate of bovine oocytes and the rate of cumulus expansion, and increased mRNA expression of genes associated with cumulus expansion. [1] Iloprost reduces the occurrence of apoptosis in COC cells and promotes an anti-apoptotic balance in the transcription of apoptosis-related genes (BAX and BCL2). [1]
In vivo	0.3 mg/kg/min Iloprost, administered intravenously by minipump for 33 days, showed significant anti-metastatic activity in a rat model of spontaneous metastatic tumors.[3] 0.2 mg/kg/day Iloprost, administered intravenously for 10 days, attenuated the effects of hyperoxia and reduced inflammation in the lungs of neonatal mice, where cyclooxygenase-2 (COX-2/PTGS2) mediated hyperoxia-induced injury.[2]
Synonyms	ZK 36374, Ciloprost

Chemical Properties

Molecular Weight	360.49
Formula	C₂₂H₃₂O₄
Cas No.	78919-13-8
Smiles	C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (221.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7740 mL	13.8700 mL	27.7400 mL	138.7001 mL
5 mM	0.5548 mL	2.7740 mL	5.5480 mL	27.7400 mL
10 mM	0.2774 mL	1.3870 mL	2.7740 mL	13.8700 mL
20 mM	0.1387 mL	0.6935 mL	1.3870 mL	6.9350 mL
50 mM	0.0555 mL	0.2774 mL	0.5548 mL	2.7740 mL
100 mM	0.0277 mL	0.1387 mL	0.2774 mL	1.3870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc