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Iloprost

Name: Iloprost
Brand: TargetMol
SKU: T15560
Rating: 4.5 (1 reviews)

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Catalog No. T15560Cas No. 78919-13-8

Alias ZK 36374, Ciloprost

Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.

Iloprost

😃Good

Catalog No. T15560Alias ZK 36374, CiloprostCas No. 78919-13-8

Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$246	35 days	35 days
500 μg	$490	35 days	35 days
1 mg	$855	35 days	35 days
5 mg	$3,650	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.
In vitro	Iloprost is a PGI2 analog that affects the maturation and developmental competence of bovine oocytes. 0.5 μM Iloprost treatment for 22-24 hours increased the blastocyst rate and the proportion of expanded blastocysts in bovine embryos, increased the maturation rate of bovine oocytes and the rate of cumulus expansion, and increased mRNA expression of genes associated with cumulus expansion. [1] Iloprost reduces the occurrence of apoptosis in COC cells and promotes an anti-apoptotic balance in the transcription of apoptosis-related genes (BAX and BCL2). [1]
In vivo	0.3 mg/kg/min Iloprost, administered intravenously by minipump for 33 days, showed significant anti-metastatic activity in a rat model of spontaneous metastatic tumors.[3] 0.2 mg/kg/day Iloprost, administered intravenously for 10 days, attenuated the effects of hyperoxia and reduced inflammation in the lungs of neonatal mice, where cyclooxygenase-2 (COX-2/PTGS2) mediated hyperoxia-induced injury.[2]
Synonyms	ZK 36374, Ciloprost

Chemical Properties

Molecular Weight	360.49
Formula	C₂₂H₃₂O₄
Cas No.	78919-13-8
Smiles	C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]
Relative Density.	1.21g/cm3
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (221.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.15 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7740 mL	13.8700 mL	27.7400 mL	138.7001 mL
5 mM	0.5548 mL	2.7740 mL	5.5480 mL	27.7400 mL
10 mM	0.2774 mL	1.3870 mL	2.7740 mL	13.8700 mL
20 mM	0.1387 mL	0.6935 mL	1.3870 mL	6.9350 mL
50 mM	0.0555 mL	0.2774 mL	0.5548 mL	2.7740 mL
100 mM	0.0277 mL	0.1387 mL	0.2774 mL	1.3870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc