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Terlakiren

Name: Terlakiren
Brand: TargetMol
SKU: T28950
Price: 377 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28950Cas No. 119625-78-4

Alias CP-80,794, CP 80794

Terlakiren (CP-80,794) is an orally active, potent renin inhibitor used in the study of neurological disorders related to hypertension.

Terlakiren

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Purity: 99.38%

Catalog No. T28950Alias CP-80,794, CP 80794Cas No. 119625-78-4

Terlakiren (CP-80,794) is an orally active, potent renin inhibitor used in the study of neurological disorders related to hypertension.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$377	In Stock	In Stock
5 mg	$810	In Stock	In Stock
10 mg	$886	In Stock	In Stock
25 mg	$996	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.38%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR ORP HPLC

Product Introduction

Terlakiren AI Summary

Terlakiren shows potent bioactivity by inhibiting monkey plasma renin with an IC50 ranging from 0.2 nM to 0.5 nM, human plasma renin with an IC50 of 0.7 nM, and guinea pig plasma renin with an IC50 of 0.3 nM. It also inhibits Bovine Cathepsin D with an IC50 of 24.0 nM. Additionally, Terlakiren causes a maximum fall in mean arterial blood pressure by 9.0 mmHg following a 30 mg/kg dose in monkeys..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Terlakiren (CP-80,794) is an orally active, potent renin inhibitor used in the study of neurological disorders related to hypertension.
Synonyms	CP-80,794, CP 80794

Chemical Properties

Molecular Weight	620.8
Formula	C₃₁H₄₈N₄O₇S
Cas No.	119625-78-4
Smiles	[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@H](C(OC(C)C)=O)O)=O)CSC)=O)NC(=O)N3CCOCC3
Relative Density.	1.205g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (29.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6108 mL	8.0541 mL	16.1082 mL	80.5412 mL
5 mM	0.3222 mL	1.6108 mL	3.2216 mL	16.1082 mL
10 mM	0.1611 mL	0.8054 mL	1.6108 mL	8.0541 mL
20 mM	0.0805 mL	0.4027 mL	0.8054 mL	4.0271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc