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4-Hydroxymephenytoin

🥰Excellent
Catalog No. T10147Cas No. 61837-65-8
Alias (+/-)-4'-Hydroxymephenytoin

4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.

4-Hydroxymephenytoin

4-Hydroxymephenytoin

🥰Excellent
Purity: 99.78%
Catalog No. T10147Alias (+/-)-4'-HydroxymephenytoinCas No. 61837-65-8
4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$72In Stock
10 mg$113In Stock
25 mg$228In Stock
50 mg$372In Stock
100 mg$597In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.78%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.
In vitro
4-Hydroxymephenytoin, a metabolite of the antiepileptic drug mephenytoin, serves as a CYP2C19 substrate[1]. It is utilized in the development of UltraPerformance LC (UPLC) tandem mass spectrometry assays to assess CYP probe drugs and their pertinent metabolites in human urine or plasma samples[2].
Synonyms(+/-)-4'-Hydroxymephenytoin
Chemical Properties
Molecular Weight234.25
FormulaC12H14N2O3
Cas No.61837-65-8
SmilesCCC1(NC(=O)N(C)C1=O)c1ccc(O)cc1
Relative Density.1.249 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (384.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2689 mL21.3447 mL42.6894 mL213.4472 mL
5 mM0.8538 mL4.2689 mL8.5379 mL42.6894 mL
10 mM0.4269 mL2.1345 mL4.2689 mL21.3447 mL
20 mM0.2134 mL1.0672 mL2.1345 mL10.6724 mL
50 mM0.0854 mL0.4269 mL0.8538 mL4.2689 mL
100 mM0.0427 mL0.2134 mL0.4269 mL2.1345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Keywords

DrugMetaboliteDrug Metabolite4-Hydroxymephenytoin4'-Hydroxymephenytoin
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