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BI8626

🥰Excellent
Catalog No. T14569Cas No. 1875036-75-1

BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.

BI8626

BI8626

🥰Excellent
Purity: 98.66%
Catalog No. T14569Cas No. 1875036-75-1
BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$84-In Stock
5 mg$198In StockIn Stock
10 mg$289In StockIn Stock
25 mg$513-In Stock
50 mg$728-In Stock
100 mg$985-In Stock
200 mg$1,330-In Stock
1 mL x 10 mM (in DMSO)$226-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.66%
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Product Introduction

Bioactivity
Description
BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.
Targets&IC50
HUWE1:0.9 μM
In vitro
In LS174T cells, BI8626 (0μM, 5μM, 10μM, 15μM, 20μM; 0-4 days) delayed progression through all phases of the cell cycle, with the most pronounced effect on the G1 phase[1].
Chemical Properties
Molecular Weight440.54
FormulaC25H28N8
Cas No.1875036-75-1
SmilesNCc1cccc(CNc2ncnc3c(ncnc23)N2CCN(Cc3ccccc3)CC2)c1
Relative Density.1.302 g/cm3 (Predicted)
ColorYellow
AppearanceViscous
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (136.2 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.54 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2699 mL11.3497 mL22.6994 mL113.4971 mL
5 mM0.4540 mL2.2699 mL4.5399 mL22.6994 mL
10 mM0.2270 mL1.1350 mL2.2699 mL11.3497 mL
20 mM0.1135 mL0.5675 mL1.1350 mL5.6749 mL
50 mM0.0454 mL0.2270 mL0.4540 mL2.2699 mL
100 mM0.0227 mL0.1135 mL0.2270 mL1.1350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HUWE1E3EnzymeE3 EnzymeE2EnzymeE2 EnzymeE1EnzymeE1 EnzymeBI-8626BI8626BI 8626
Related Tags: buy BI8626 | purchase BI8626 | BI8626 cost | order BI8626 | BI8626 chemical structure | BI8626 in vitro | BI8626 formula | BI8626 molecular weight
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