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Hedgehog IN-6

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Catalog No. T209234Cas No. 2916444-33-0

HedgehogIN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor utilized in cancer research. It inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterol modification.

Hedgehog IN-6

Hedgehog IN-6

😃Good
Catalog No. T209234Cas No. 2916444-33-0
HedgehogIN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor utilized in cancer research. It inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterol modification.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
HedgehogIN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor utilized in cancer research. It inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterol modification.
In vitro
Q29 (1-10 μM; 24 hours) inhibits GLI1 protein expression activated by Shh-N in a dose-dependent manner. Q29 (1-10 μM; 24 + 12 hours) also suppresses Hh signal-dependent cell proliferation in a dose-dependent way. Under varying concentrations of Shh-N, Q29 inhibits Gli-luciferase activity, with an IC50 of 1.33 μM.
In vivo
When administered orally via gavage at a dose of Q29 (90 mg/kg; twice daily for 13 days), it effectively inhibits tumor growth in Ptch1+/P53/ mice.
Chemical Properties
Molecular Weight389.61
FormulaC25H43NO2
Cas No.2916444-33-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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