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N-Phenylthiourea

Name: N-Phenylthiourea
Brand: TargetMol
SKU: T72009
Rating: 4.5 (1 reviews)

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Catalog No. T72009Cas No. 103-85-5

Alias Phenylthiourea, Phenylthiocarbamide

N-Phenylthiourea (Phenylthiocarbamide) is a phenyl ring-containing organothiourea that acts as an EC 1.14.18.1 (tyrosinase) inhibitor, a diphenolase inhibitor, and a non-competitive inhibitor of the PvdP tyrosinase of Pseudomonas, which inhibits melanogenesis, and is able to be used in genetic taste testing.

N-Phenylthiourea

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Purity: 99.71%

Catalog No. T72009Alias Phenylthiourea, PhenylthiocarbamideCas No. 103-85-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 g	$30	6-8 weeks	6-8 weeks
25 g	$40	35 days	35 days
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.71%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	N-Phenylthiourea (Phenylthiocarbamide) is a phenyl ring-containing organothiourea that acts as an EC 1.14.18.1 (tyrosinase) inhibitor, a diphenolase inhibitor, and a non-competitive inhibitor of the PvdP tyrosinase of Pseudomonas, which inhibits melanogenesis, and is able to be used in genetic taste testing.
In vitro	N-Phenylthiourea acts as a reversible competitive inhibitor of tyrosinase in DOPA oxidation assays (Ki = 0.21 μM), significantly reducing DOPA-chrome formation[1].
In vivo	In zebrafish embryos, co-treatment with N-Phenylthiourea (100 μM) and HgCl₂ significantly reduced mercury toxicity, with both mortality and hepatic Hg levels decreasing by 60-fold. In contrast, co-treatment with CH₃HgCl increased toxicity, leading to higher mortality and a 2-fold increase in hepatic Hg accumulation. These results indicate that N-Phenylthiourea has opposite modulatory effects on the toxicity of inorganic and organic mercury[2].
Synonyms	Phenylthiourea, Phenylthiocarbamide

Chemical Properties

Molecular Weight	152.22
Formula	C₇H₈N₂S
Cas No.	103-85-5
Smiles	S=C(N)NC=1C=CC=CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (525.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (21.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5694 mL	32.8472 mL	65.6944 mL	328.4719 mL
5 mM	1.3139 mL	6.5694 mL	13.1389 mL	65.6944 mL
10 mM	0.6569 mL	3.2847 mL	6.5694 mL	32.8472 mL
20 mM	0.3285 mL	1.6424 mL	3.2847 mL	16.4236 mL
50 mM	0.1314 mL	0.6569 mL	1.3139 mL	6.5694 mL
100 mM	0.0657 mL	0.3285 mL	0.6569 mL	3.2847 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

N-Phenylthiourea

N-Phenylthiourea

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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