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Imarikiren HCl (Synonyms: TAK-272 hydrochloride, TAK-272 HCl. Imarikiren HCl , |TAK-272, TAK272, TAK 272)

Catalog No. T27595 Copy Product Info
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Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 > 10 μM) and pepsin (IC50 > 10 μM). TAK-272 exhibits a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive efficacy in a dose-dependent manner.

Imarikiren HCl

Copy Product Info
🥰Excellent
Catalog No. T27595
Synonyms TAK-272 hydrochloride, TAK-272 HCl. Imarikiren HCl , |TAK-272, TAK272, TAK 272

Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 > 10 μM) and pepsin (IC50 > 10 μM). TAK-272 exhibits a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive efficacy in a dose-dependent manner.

Imarikiren HCl
Cas No. 1202269-24-6
Other Forms of Imarikiren HCl:
ImarikirenT2023951202265-63-1
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Pack SizePriceUSA StockGlobal StockQuantity
25 mg$1,9708-10 weeks8-10 weeks
50 mg$2,5808-10 weeks8-10 weeks
100 mg$3,4008-10 weeks8-10 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Product Introduction

Bioactivity
Description
Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 > 10 μM) and pepsin (IC50 > 10 μM). TAK-272 exhibits a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive efficacy in a dose-dependent manner.
SynonymsTAK-272 hydrochloride, TAK-272 HCl. Imarikiren HCl , |TAK-272, TAK272, TAK 272
Chemical Properties
Molecular Weight536.11
FormulaC27H42ClN5O4
Cas No.1202269-24-6
SmilesC(CCCOC)N1C(C(N(CC(C)C)[C@H]2C[C@@H](C(=O)N3CCOCC3)CNC2)=O)=NC=4C1=CC=CC4.Cl
Relative Density.1.31g/cm3
Storage & Solubility Information
StorageShipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAK-272 HydrochlorideTAK272 HydrochlorideTAK 272 HydrochlorideImarikiren HCl
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