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2-Benzothiazolamine

Name: 2-Benzothiazolamine
Brand: TargetMol
SKU: T1347
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1347Cas No. 136-95-8

Alias 2-Aminobenzothiazole

2-Benzothiazolamine (2-ABT) is a nitrogen-containing heterocyclic compound used as a reaction intermediate in the synthesis of a variety of drugs. It inhibits cytochrome P450 activity and has also shown anti-inflammatory, anticonvulsant and anticancer activities in animal models.

2-Benzothiazolamine

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Purity: 99.3%

Catalog No. T1347Alias 2-AminobenzothiazoleCas No. 136-95-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.3%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

2-Benzothiazolamine AI Summary

2-Benzothiazolamine exhibits diverse bioactivities across various assays. It binds to ErmAM methylase with a Kd value of 1,000,000 nM, indicating weak affinity. It protects against glutamic acid-evoked convulsions in rats (ED50 > 10.0 mg/kg) and has a cLogP value of 2.0. With a pKa of 4.32, it shows distinct behavior in different pH environments. As an antioxidant, it scavenges DPPH free radicals (IC50 > 4,000,000 nM). It inhibits Leishmania major PTR1 with a Ki of 143,000 nM and an IC50 of 1,800,000 nM, suggesting antiparasitic potential. In cellular assays, it induces cell cycle arrest in MCF7 cells, affecting G1, S, and G2/M phases. It has a LogP of 2.43 and limited antimicrobial activity against tested microorganisms. The compound shows MIC values > 512.0 ug/mL against several Candida species and bacteria like E. coli and S. aureus. 2-Benzothiazolamine activates AMPK in rat L6 cells, enhancing [3H]dGlc uptake. It exhibits weak IDO1 inhibition (21.0% at 1 mM L-tryptophan) and moderate human liver microsome metabolism (CL value of 17.78 mL.min-1.g-1). Moreover, it inhibits D-amino acid oxidase by 27.0% at 20 uM and shows low covalent inhibition and binding affinity to p47phox SH3A-B domain (Ki > 2,000,000 nM). Additionally, it manifests varied inhibitory activities including against ROR gamma, DNA repair mechanisms, Hepatitis C Virus, and antimalarial pathways. However, it shows no significant inhibitory activity on rat and human VAP-1..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Benzothiazolamine (2-ABT) is a nitrogen-containing heterocyclic compound used as a reaction intermediate in the synthesis of a variety of drugs. It inhibits cytochrome P450 activity and has also shown anti-inflammatory, anticonvulsant and anticancer activities in animal models.
Synonyms	2-Aminobenzothiazole

Chemical Properties

Molecular Weight	150.2
Formula	C₇H₆N₂S
Cas No.	136-95-8
Smiles	NC1=NC2=CC=CC=C2S1
Relative Density.	1.2162 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (366.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6578 mL	33.2889 mL	66.5779 mL	332.8895 mL
5 mM	1.3316 mL	6.6578 mL	13.3156 mL	66.5779 mL
10 mM	0.6658 mL	3.3289 mL	6.6578 mL	33.2889 mL
20 mM	0.3329 mL	1.6644 mL	3.3289 mL	16.6445 mL
50 mM	0.1332 mL	0.6658 mL	1.3316 mL	6.6578 mL
100 mM	0.0666 mL	0.3329 mL	0.6658 mL	3.3289 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc