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TPO Protein, Human, Recombinant (His)

Catalog No. TMPJ-00235
Synonyms: Megakaryocyte growth and development factor, C-mpl ligand, Thrombopoietin, Myeloproliferative leukemia virus oncogene ligand, THPO, Megakaryocyte colony-stimulating factor

Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

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TPO Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
20 μg 5 days $ 190.00
50 μg 5 days $ 350.00
100 μg 5 days $ 513.00
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Biological Description
Technical Params
Product Properties
Description Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Species Human
Expression System Human Cells
Tag N,C-6His
Accession Number P40225
Synonyms Megakaryocyte growth and development factor, C-mpl ligand, Thrombopoietin, Myeloproliferative leukemia virus oncogene ligand, THPO, Megakaryocyte colony-stimulating factor
Amino Acid Ser22-Gly353
Construction Recombinant Human Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22-Gly353 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 70-90 KDa, reducing conditions
Endotoxin Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

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Keywords

TPO Protein, Human, Recombinant (His) Megakaryocyte growth and development factor C-mpl ligand Thrombopoietin Myeloproliferative leukemia virus oncogene ligand THPO Megakaryocyte colony-stimulating factor recombinant recombinant-proteins proteins protein

 

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