Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Nylidrin

Name: Nylidrin
Brand: TargetMol
SKU: T69239
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T69239Cas No. 447-41-6

Alias Buphenine

Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.

Nylidrin

😃Good

Catalog No. T69239Alias BuphenineCas No. 447-41-6

Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$113	35 days	35 days
10 mg	$198	35 days	35 days
25 mg	$420	35 days	35 days
50 mg	$722	35 days	35 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.
In vitro	Nylidrin is a potent antagonist of NR1A/2B receptor expressed in Xenopus oocytes with IC50 = 0.18 μM. Nylidrin inhibits the NMDA response in cultured rat cortical neurons with a potency and mechanism of action similar to that of NR1A/2B receptors. [1] Nylidrin (0, 40, and 400 μM) targets hemagglutinin 2 (HA2) -mediated membrane fusion by blocking the conformational change of HA at acidic pH. [2]
In vivo	In mouse models, preincubation of mouse influenza A virus (H1N1) with Nylidrin completely blocked intranasal viral infection. [2]
Synonyms	Buphenine

Chemical Properties

Molecular Weight	299.41
Formula	C₁₉H₂₅NO₂
Cas No.	447-41-6
Smiles	OC1=CC=C(C=C1)C(O)C(NC(C)CCC=2C=CC=CC2)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nylidrin