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5-Hydroxydecanoate sodium

🥰Excellent
Catalog No. T29457LCas No. 71186-53-3

5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with an IC50 of approximately 30 μM and a substrate for mitochondrial outer membrane acyl-CoA synthetase, possessing antioxidant properties.

5-Hydroxydecanoate sodium
Other Forms of 5-Hydroxydecanoate sodium:
5-Hydroxydecanoic acidT29457624-00-0
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5-Hydroxydecanoate sodium

🥰Excellent
Purity: 99.89%
Catalog No. T29457LCas No. 71186-53-3
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with an IC50 of approximately 30 μM and a substrate for mitochondrial outer membrane acyl-CoA synthetase, possessing antioxidant properties.
Pack SizePriceAvailabilityQuantity
25 mg$31In Stock
50 mg$56In Stock
100 mg$83In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Purity:99.89%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with an IC50 of approximately 30 μM and a substrate for mitochondrial outer membrane acyl-CoA synthetase, possessing antioxidant properties.
Targets&IC50
K+-ATP channel:30 μM
In vitro
The treatment of 5-Hydroxydecanoate sodium abolished the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate sodium blocked the inhibitory effect of PHC on Ca2+ overload and ROS production and promoted the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate sodium attenuated the anti-apoptotic effect of PHC[1].
In vivo
The treatment of 5-Hydroxydecanoate sodium (100 μM) abolished the effects of ischemic preconditioning (IPC) on the contractile recovery, but 5-Hydroxydecanoate sodium did not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[2].
Chemical Properties
Molecular Weight210.25
FormulaC10H19NaO3
Cas No.71186-53-3
SmilesO=C(CCCC(CCCCC)O)[O-].[Na+]
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.6 mg/mL (17.12 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.7562 mL23.7812 mL47.5624 mL237.8121 mL
5 mM0.9512 mL4.7562 mL9.5125 mL47.5624 mL
10 mM0.4756 mL2.3781 mL4.7562 mL23.7812 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PotassiumChannelPotassium ChannelATP-sensitive potassium (KATP) channels5-Hydroxydecanoate sodium5Hydroxydecanoate sodium5 Hydroxydecanoate sodium
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