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N-Acetyl-L-phenylalanine (Synonyms: N-Ac-Phenylalanine)

Name: N-Acetyl-L-phenylalanine
Brand: TargetMol
SKU: T4781
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T4781 Copy Product Info

Purity: 99.74%

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N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) is an essential amino acid produced for medical, feed, and nutritional applications. It appears in large amount in urine of patients with phenylketonuria which is a human genetic disorder due to the lack of phenylalanine hydroxylase, the enzyme necessary to metabolize phenylalanine to tyrosine. Acetylphenylalanine is a product of enzyme phenylalanine N-acetyltransferase in the pathway phenylalanine metabolism.

N-Acetyl-L-phenylalanine

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Catalog No. T4781

Synonyms N-Ac-Phenylalanine

Cas No. 2018-61-3

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Pack Size	Price	USA Stock	Global Stock
100 mg	$31	In Stock	In Stock
500 mg	$58	-	In Stock
1 g	$81	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

N-Acetyl-L-phenylalanine AI Summary

N-Acetyl-L-phenylalanine inhibits the uptake of L-tryptophan in Xenopus laevis oocytes, showing varying degrees of inhibition (from 90% to 100%), indicating potential bioactivity related to tryptophan transport processes. The compound also exhibits antiviral activity against SARS-CoV-2, inhibiting the cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, showing inhibition rates of 20.55% and 0.1% respectively after 48 hours. Additionally, N-Acetyl-L-phenylalanine has demonstrated 13.69% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, suggesting its role in interfering with the virus's replication process. Furthermore, it shows inhibitory activity towards the human HDAC6 enzyme with 4.6% inhibition using a commercial peptide substrate and -7.32% inhibition using a custom peptide substrate, indicating its potential as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

N-Ac-Phenylalanine

Chemical Properties

Molecular Weight	207.23
Formula	C₁₁H₁₃NO₃
Cas No.	2018-61-3
Smiles	[H][C@](Cc1ccccc1)(NC(C)=O)C(O)=O
Relative Density.	1.1878 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1206.39 mM), Sonication is recommended.

Ethanol: 20 mg/mL (96.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8256 mL	24.1278 mL	48.2556 mL	241.2778 mL
5 mM	0.9651 mL	4.8256 mL	9.6511 mL	48.2556 mL
10 mM	0.4826 mL	2.4128 mL	4.8256 mL	24.1278 mL
20 mM	0.2413 mL	1.2064 mL	2.4128 mL	12.0639 mL
50 mM	0.0965 mL	0.4826 mL	0.9651 mL	4.8256 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0483 mL	0.2413 mL	0.4826 mL	2.4128 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc