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2-Propylpent-4-ynoic acid
(Synonyms: 4-yn-VPA) Copy Product Info
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Synonyms: 4-yn-VPA
Catalog No. T218992 Copy Product Info
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2-Propylpent-4-ynoic acid (4-yn-VPA) is identified as an HDAC inhibitor, with an IC50 value of 0.5 mM against human HDAC. It induces P-glycoprotein function and exhibits teratogenic effects, fetal growth inhibition, and neurotoxicity. The compound demonstrates significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs, although its neurotoxicity is not associated with stereochemistry. This compound has been utilized in studies related to the pathogenesis of colon cancer and neural tube defects, such as exencephaly.
2-Propylpent-4-ynoic acid
Cas No. 24102-11-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2-Propylpent-4-ynoic acid (4-yn-VPA) is identified as an HDAC inhibitor, with an IC50 value of 0.5 mM against human HDAC. It induces P-glycoprotein function and exhibits teratogenic effects, fetal growth inhibition, and neurotoxicity. The compound demonstrates significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs, although its neurotoxicity is not associated with stereochemistry. This compound has been utilized in studies related to the pathogenesis of colon cancer and neural tube defects, such as exencephaly. |
| In vitro | 2-Propylpent-4-ynoic acid (4-yn-VPA) (1 mM; 5 d) can induce P-gp function in human colon adenocarcinoma SW620 cells and has an HDAC inhibition IC 50 of 0.5 mM in nuclear extracts from HeLa cells. |
| In vivo | When 2-Propylpent-4-ynoic acid (4-yn-VPA) induces exencephaly in mice, the S-(-)-4-yn-VPA isomer (0.40-1.05 mmol/kg; intraperitoneal injection; gestation day 8; single dose) is 7.5 times more potent compared to the R(+)-4-yn-VPA isomer (3-6 mmol/kg; intraperitoneal injection; gestation day 8; single dose). The ED50 values for these isomers are 0.83 mmol/kg and 6.19 mmol/kg, respectively. |
| Synonyms | 4-yn-VPA |
| Molecular Weight | 140.18 |
| Formula | C8H12O2 |
| Cas No. | 24102-11-2 |
| Smiles | O=C(O)C(CC#C)CCC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: 2-Propylpent-4-ynoic acid in vivo | 2-Propylpent-4-ynoic acid in vitro | 2-Propylpent-4-ynoic acid formula | 2-Propylpent-4-ynoic acid molecular weight
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