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L-Homocysteine

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Catalog No. T19392Cas No. 6027-13-0

L-Homocysteine is a biological thiol involved in various diseases and pathological conditions. It is a marker for atherosclerosis and can exacerbate intestinal inflammation in inflammatory bowel disease (IBD) by promoting the expression of 5-LOX and COX-2, making it suitable for inducing vascular endothelial inflammation models.

L-Homocysteine
Other Forms of L-Homocysteine:

L-Homocysteine

🥰Excellent
Purity: 99.91%
Catalog No. T19392Cas No. 6027-13-0
L-Homocysteine is a biological thiol involved in various diseases and pathological conditions. It is a marker for atherosclerosis and can exacerbate intestinal inflammation in inflammatory bowel disease (IBD) by promoting the expression of 5-LOX and COX-2, making it suitable for inducing vascular endothelial inflammation models.
Pack SizePriceAvailabilityQuantity
10 mg$30In Stock
25 mg$46In Stock
50 mg$66In Stock
100 mg$96In Stock
200 mg$139In Stock
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Purity:99.91%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
L-Homocysteine is a biological thiol involved in various diseases and pathological conditions. It is a marker for atherosclerosis and can exacerbate intestinal inflammation in inflammatory bowel disease (IBD) by promoting the expression of 5-LOX and COX-2, making it suitable for inducing vascular endothelial inflammation models.
In vitro
L-Homocysteine (100 mM, 24h) promoted the expression of cathepsin V in HUVECs and induced vascular inflammation. [2]
In vivo
L-Homocysteine induced cathepsin V expression in endothelial cells in a mouse model of hyperhomocysteinemia induced by a high methionine diet. [2]
Chemical Properties
Molecular Weight135.19
FormulaC4H9NO2S
Cas No.6027-13-0
Smiles[C@H](CCS)(C(O)=O)N
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 16 mg/mL (118.35 mM), Sonication is recommended.
DMSO: < 0.1 mg/mL (insoluble)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM7.3970 mL36.9850 mL73.9700 mL369.8498 mL
5 mM1.4794 mL7.3970 mL14.7940 mL73.9700 mL
10 mM0.7397 mL3.6985 mL7.3970 mL36.9850 mL
20 mM0.3698 mL1.8492 mL3.6985 mL18.4925 mL
50 mM0.1479 mL0.7397 mL1.4794 mL7.3970 mL
100 mM0.0740 mL0.3698 mL0.7397 mL3.6985 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

L-HomocysteineLHomocysteineL HomocysteineHuman Endogenous Metabolite
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