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Taurohyodeoxycholic acid

Catalog No. T37770 CAS 2958-04-5

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.4Taurohyodeoxycholic acid MaxSpec standard is a quantitative grade standard of taurohyodeoxycholic acid (sodium salt) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. Verified concentration is provided on the certificate of analysis. This taurohyodeoxycholic acid MaxSpec standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product.Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Taurohyodeoxycholic acid Chemical Structure

Taurohyodeoxycholic acid, CAS 2958-04-5

Pack Size	Availability	Price/USD
2 mg	5 days	$ 113.00
5 mg	5 days	$ 193.00
10 mg	5 days	$ 289.00
25 mg	5 days	$ 539.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	499.71
Formula	C26H45NO6S
CAS No.	2958-04-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Angelico, M., Mogavero, L., Baiocchi, L., et al.Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHsScand. J. Gastroenterol.30(12)1178-1185(1995) 2. Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the ratDig. Dis. Sci.39(11)2389-2397(1994) 3. Roda, A., Piazza, F., Baraldini, M., et al.Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the ratHepatology27(2)520-525(1998) 4. He, J., Liang, J., Zhu, S., et al.Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in miceEur. J. Pharmacol.670(1)229-235(2011)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Taurohyodeoxycholic acid 2958-04-5 inhibitor inhibit

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