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Taurohyodeoxycholic acid

Name: Taurohyodeoxycholic acid
Brand: TargetMol
SKU: T37770
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Taurohyodeoxycholic Acid MaxSpec® Standard) Copy Product Info

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Synonyms: Taurohyodeoxycholic Acid MaxSpec® Standard

Catalog No. T37770 Copy Product Info

Purity: 99.38%

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Taurohyodeoxycholic acid (THDCA) is a bile acid that plays a key role in regulating the hepatic inflammatory microenvironment.THDCA reduces the expression of TNF-α and IL-6 and inhibits the development of hepatocellular carcinoma (HCC). It is able to inhibit non-alcoholic fatty liver disease and regulate bile acid metabolism in combination with astragalus polysaccharides: it reduces CD36 expression in the liver and decreases hepatic lipid accumulation by up-regulating CYP7B1 and down-regulating CYP7A1.

Cas No. 2958-04-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$42	-	In Stock
5 mg	$98	-	In Stock
10 mg	$163	-	In Stock
25 mg	$289	-	In Stock
50 mg	$413	-	In Stock
100 mg	$662	-	In Stock
1 mL x 10 mM (in DMSO)	$108	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Synonyms

Taurohyodeoxycholic Acid MaxSpec® Standard

Chemical Properties

Molecular Weight	499.70
Formula	C₂₆H₄₅NO₆S
Cas No.	2958-04-5
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(NCCS(=O)(=O)O)=O)C)(CC4)[H])[H])(C[C@H](O)[C@@]1(C[C@H](O)CC2)[H])[H])[H]
Relative Density.	1.216 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (250.15 mM)

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (20.01 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0012 mL	10.0060 mL	20.0120 mL	100.0600 mL
5 mM	0.4002 mL	2.0012 mL	4.0024 mL	20.0120 mL
10 mM	0.2001 mL	1.0006 mL	2.0012 mL	10.0060 mL
20 mM	0.1001 mL	0.5003 mL	1.0006 mL	5.0030 mL
50 mM	0.0400 mL	0.2001 mL	0.4002 mL	2.0012 mL
100 mM	0.0200 mL	0.1001 mL	0.2001 mL	1.0006 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc