DHQZ 36

Name: DHQZ 36
Brand: TargetMol
SKU: T15110
Rating: 4.5 (1 reviews)

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Catalog No. T15110Cas No. 1542098-94-1

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

DHQZ 36

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Catalog No. T15110Cas No. 1542098-94-1

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).
Targets&IC50	Leishmania amazonensis:（EC50）13.63 μM
In vitro	DHQZ 36 causes over 40% reduction in secreted of parasite proteins and it also causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation. With increasing concentrations of DHQZ 36, there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM.

Chemical Properties

Molecular Weight	384.44
Formula	C₂₁H₁₈F₂N₂OS
Cas No.	1542098-94-1
Smiles	C(N1C(NC=2C(C1=O)=CC(F)=CC2)C=3SC(CC)=CC3)C4=CC=C(F)C=C4
Relative Density.	1.311 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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