DHQZ 36

Name: DHQZ 36
Brand: TargetMol
SKU: T15110
Rating: 4.5 (1 reviews)

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Catalog No. T15110Cas No. 1542098-94-1

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

DHQZ 36

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Catalog No. T15110Cas No. 1542098-94-1

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).
Targets&IC50	Leishmania amazonensis:（EC50）13.63 μM
In vitro	DHQZ 36 causes over 40% reduction in secreted of parasite proteins and it also causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation. With increasing concentrations of DHQZ 36, there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM.

Chemical Properties

Molecular Weight	384.44
Formula	C₂₁H₁₈F₂N₂OS
Cas No.	1542098-94-1
Relative Density.	1.311 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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