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FR194738

Name: FR194738
Brand: TargetMol
SKU: T11320
Rating: 4.5 (1 reviews)

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Catalog No. T11320Cas No. 204067-52-7

FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.

FR194738

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Catalog No. T11320Cas No. 204067-52-7

FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,840	1-2 weeks	1-2 weeks
50 mg	$2,390	1-2 weeks	1-2 weeks
100 mg	$3,400	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.
Targets&IC50	SE (HepG2 cell homogenates):9.8 nM
In vitro	FR194738 inhibits cholesterol biosynthesis in HepG2 cells (IC50 = 2.1 nM)[1]. FR194738 concentration-dependently inhibits hamster liver microsomal squalene epoxidase activity (IC50 = 14 nM)[2]. FR194738 inhibits the incorporation of [14C]acetate in intact HepG2 cells into free cholesterol (IC50 = 4.9 nM) and cholesteryl ester (IC50 = 8.0 nM) in a concentration-dependent manner. FR194738 induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene[3].
In vivo	FR194738 (32 and 100 mg/kg) reduces the serum levels of total, non HDL and HDL cholesterol, and triglyceride and increases HMG-CoA reductase activity by 1.3-fold at a dose of 32 mg/kg[2].

Chemical Properties

Molecular Weight	476.11
Formula	C₂₇H₃₈ClNO₂S
Cas No.	204067-52-7
Smiles	Cl.CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (420.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1004 mL	10.5018 mL	21.0035 mL	105.0177 mL
5 mM	0.4201 mL	2.1004 mL	4.2007 mL	21.0035 mL
10 mM	0.2100 mL	1.0502 mL	2.1004 mL	10.5018 mL
20 mM	0.1050 mL	0.5251 mL	1.0502 mL	5.2509 mL
50 mM	0.0420 mL	0.2100 mL	0.4201 mL	2.1004 mL
100 mM	0.0210 mL	0.1050 mL	0.2100 mL	1.0502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc