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Metalaxyl

Name: Metalaxyl
Brand: TargetMol
SKU: T20066
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20066Cas No. 57837-19-1

Alias Ridomil MZ 72 WP, Metalaxil, CGA-48988, CGA48988, CGA 48988, Allegiance

Metalaxyl (CGA 48988) is a widely used fungicide that inhibits protein synthesis in fungi, interferes with skeletal development in zebrafish embryos, and can be used to control plant diseases caused by oomycetous fungi.

Metalaxyl

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Purity: 99.77%

Catalog No. T20066Alias Ridomil MZ 72 WP, Metalaxil, CGA-48988, CGA48988, CGA 48988, AllegianceCas No. 57837-19-1

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$48	-	In Stock
500 mg	$113	-	In Stock
1 g	$166	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Metalaxyl (CGA 48988) is a widely used fungicide that inhibits protein synthesis in fungi, interferes with skeletal development in zebrafish embryos, and can be used to control plant diseases caused by oomycetous fungi.
Targets&IC50	pathogenic Aspergillus oryzae fungi:0.3 to 3.9 μg/mL (EC50)
In vitro	Metalaxyl showed potent inhibition of pathogenic Aspergillus oryzae fungi isolated from a potato field in Serbia, with EC50 values ranging from 0.3 to 3.9 μg/mL.[1]
In vivo	In albino rats, Metalaxyl treatment induced dose-dependent bradycardia, with sustained bradycardia culminating in cardiac arrest at higher doses (250 and 300 mg/kg). In addition, acetylcholinesterase activity in the brain and heart of rats was not altered by Metalaxyl treatment. [2]
Synonyms	Ridomil MZ 72 WP, Metalaxil, CGA-48988, CGA48988, CGA 48988, Allegiance

Chemical Properties

Molecular Weight	279.33
Formula	C₁₅H₂₁NO₄
Cas No.	57837-19-1
Smiles	O=C(OC)C(N(C(=O)COC)C=1C(=CC=CC1C)C)C
Relative Density.	1.117 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (286.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5800 mL	17.9000 mL	35.7999 mL	178.9997 mL
5 mM	0.7160 mL	3.5800 mL	7.1600 mL	35.7999 mL
10 mM	0.3580 mL	1.7900 mL	3.5800 mL	17.9000 mL
20 mM	0.1790 mL	0.8950 mL	1.7900 mL	8.9500 mL
50 mM	0.0716 mL	0.3580 mL	0.7160 mL	3.5800 mL
100 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc