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3′-Oxolutein
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Catalog No. TN11549Cas No. 23984-55-6
Alias Philosamiaxanthin, 3'-Dehydrolutein
3′-Oxolutein, a metabolite of dietary lutein, acts as an anti-inflammatory and antioxidant agent. It reduces glutamate-induced reactive oxygen species (ROS) production and the secretion of pro-inflammatory cytokines in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels and increases thiol levels. This compound is useful for inflammation-related research.
3′-Oxolutein
😃Good
Catalog No. TN11549Alias Philosamiaxanthin, 3'-DehydroluteinCas No. 23984-55-6
3′-Oxolutein, a metabolite of dietary lutein, acts as an anti-inflammatory and antioxidant agent. It reduces glutamate-induced reactive oxygen species (ROS) production and the secretion of pro-inflammatory cytokines in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels and increases thiol levels. This compound is useful for inflammation-related research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3′-Oxolutein, a metabolite of dietary lutein, acts as an anti-inflammatory and antioxidant agent. It reduces glutamate-induced reactive oxygen species (ROS) production and the secretion of pro-inflammatory cytokines in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels and increases thiol levels. This compound is useful for inflammation-related research. |
| In vitro | 3'-Oxolutein (10 ng/μL, 10-30 min) significantly reduces the production of reactive oxygen species (ROS) induced by glutamate in SH-SY5Y cells. When applied for 24-72 hours, 3'-Oxolutein increases small molecule antioxidant levels at 48 hours but does not alter the total antioxidant capacity (TAC) in glutamate-treated SH-SY5Y cells. Additionally, treatment with 3'-Oxolutein (10 ng/μL, 24-72 h) alone does not affect superoxide dismutase (SOD) activity nor prevent the decrease in SOD activity in glutamate-treated SH-SY5Y cells. It can, however, reduce iron content and decrease mRNA expression of the ALOX5, ALOX15, and ACSL4 genes induced by glutamate in SH-SY5Y cells. Furthermore, 3'-Oxolutein (10 ng/μL, 24-72 h) does not significantly impact IL-6 secretion but reduces glutamate-induced IL-8 secretion and decreases TNFα levels in SH-SY5Y cells. |
| Synonyms | Philosamiaxanthin, 3'-Dehydrolutein |
| Molecular Weight | 566.86 |
| Formula | C40H54O2 |
| Cas No. | 23984-55-6 |
| Smiles | C(=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=1C(C)(C)C[C@H](O)CC1C)\C)\C)/C)/C)\[C@@H]2C(C)(C)CC(=O)C=C2C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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