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Oxyfedrine L-form HCl

Name: Oxyfedrine L-form HCl
Brand: TargetMol
SKU: T24579
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24579Cas No. 16777-42-7

Alias Oxyfedrine L-form hydrochloride, Modacor, Ildamen, D-563, D563, D 563

Oxyfedrine L-form HCl (Ildamen) is a partial agonist at beta-adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.

Oxyfedrine L-form HCl

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Purity: 99.57%

Catalog No. T24579Alias Oxyfedrine L-form hydrochloride, Modacor, Ildamen, D-563, D563, D 563Cas No. 16777-42-7

Oxyfedrine L-form HCl (Ildamen) is a partial agonist at beta-adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$538	In Stock	In Stock
50 mg	$778	In Stock	In Stock
100 mg	$993	In Stock	In Stock
200 mg	$1,330	-	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Oxyfedrine L-form HCl AI Summary

Oxyfedrine L-form HCl exhibits a range of bioactivities, including the inhibition of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with varying potencies, potential gametocytocidal properties, and the ability to block the entry of the Ebola virus. Notably, this compound also demonstrates significant antiviral activities against SARS-CoV-2. It shows a 6.41% inhibition of cytotoxicity in Caco-2 cells at a concentration of 10 μM after 48 hours. Additionally, Oxyfedrine L-form HCl inhibits the SARS-CoV-2 3CL-Pro protease with 91.57% inhibition at 20 μM and an IC50 of 2350.0 nM, though it is less effective against the MERS 3CL-Pro protease, with an inhibition percentage of 19.0% at 10 μM and an IC50 greater than 10000.0 nM. Moreover, the compound exhibits minimal inhibition of virus-induced cytotoxicity in VERO-6 cells, with an inhibition rate of 0.03% at 10 μM after 48 hours. Oxyfedrine L-form HCl shows potency in the nanomolar and micromolar ranges across various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxyfedrine L-form HCl (Ildamen) is a partial agonist at beta-adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.
Synonyms	Oxyfedrine L-form hydrochloride, Modacor, Ildamen, D-563, D563, D 563

Chemical Properties

Molecular Weight	349.85
Formula	C₁₉H₂₄ClNO₃
Cas No.	16777-42-7
Smiles	C(CCN[C@H]([C@H](O)C1=CC=CC=C1)C)(=O)C2=CC(OC)=CC=C2.Cl
Relative Density.	1.122g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (128.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8584 mL	14.2918 mL	28.5837 mL	142.9184 mL
5 mM	0.5717 mL	2.8584 mL	5.7167 mL	28.5837 mL
10 mM	0.2858 mL	1.4292 mL	2.8584 mL	14.2918 mL
20 mM	0.1429 mL	0.7146 mL	1.4292 mL	7.1459 mL
50 mM	0.0572 mL	0.2858 mL	0.5717 mL	2.8584 mL
100 mM	0.0286 mL	0.1429 mL	0.2858 mL	1.4292 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc