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PDE5-IN-3

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Catalog No. T62681Cas No. 2538149-57-2

PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.

PDE5-IN-3

PDE5-IN-3

😃Good
Catalog No. T62681Cas No. 2538149-57-2
PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.
Targets&IC50
PDE5:1.57 nM, EGFR:5.827 μM
Chemical Properties
Molecular Weight448.27
FormulaC21H14BrN5O2
Cas No.2538149-57-2
SmilesO=C1C2=C(N(N=C2)C3=CC=C(Br)C=C3)NC(=N1)C=4C(OC)=NC5=C(C4)C=CC=C5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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