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Leteprinim
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Catalog No. T32658LCas No. 138117-50-7
Alias AIT-082 acid, AIT082 acid, AIT 082 acid
Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.
Leteprinim
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Purity: 99.08%
Catalog No. T32658LAlias AIT-082 acid, AIT082 acid, AIT 082 acidCas No. 138117-50-7
Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $89 | In Stock | In Stock | |
| 2 mg | $126 | In Stock | In Stock | |
| 5 mg | $197 | In Stock | In Stock | |
| 10 mg | $298 | In Stock | In Stock | |
| 25 mg | $476 | In Stock | In Stock | |
| 50 mg | $678 | In Stock | In Stock | |
| 100 mg | $912 | - | In Stock | |
| 200 mg | $1,220 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.08%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes. |
| In vitro | Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury[3]. |
| In vivo | Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats[2]. |
| Synonyms | AIT-082 acid, AIT082 acid, AIT 082 acid |
| Molecular Weight | 327.29 |
| Formula | C15H13N5O4 |
| Cas No. | 138117-50-7 |
| Smiles | C(CC(NC1=CC=C(C(O)=O)C=C1)=O)N2C3=C(C(=O)N=CN3)N=C2 |
| Relative Density. | 1.57 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (38.19 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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