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Necroptosis-IN-3

🥰Excellent
Catalog No. T64349Cas No. 547698-18-0
Alias Cyclohexanecarboxamide, N-(2-thienylmethyl)-

Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.

Necroptosis-IN-3

Necroptosis-IN-3

🥰Excellent
Purity: 99.85%
Catalog No. T64349Alias Cyclohexanecarboxamide, N-(2-thienylmethyl)-Cas No. 547698-18-0
Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
Pack SizePriceAvailabilityQuantity
25 mg$48In Stock
50 mg$74In Stock
100 mg$112In Stock
200 mg$189In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:99.85%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
In vitro
TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) inhibits TNF-α-induced necrosis in FADD-deficient human Jurkat T cells [1].
SynonymsCyclohexanecarboxamide, N-(2-thienylmethyl)-
Chemical Properties
Molecular Weight223.33
FormulaC12H17NOS
Cas No.547698-18-0
SmilesC(NCC1=CC=CS1)(=O)C2CCCCC2
Relative Density.1.135 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (246.27 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.4777 mL22.3884 mL44.7768 mL223.8839 mL
5 mM0.8955 mL4.4777 mL8.9554 mL44.7768 mL
10 mM0.4478 mL2.2388 mL4.4777 mL22.3884 mL
20 mM0.2239 mL1.1194 mL2.2388 mL11.1942 mL
50 mM0.0896 mL0.4478 mL0.8955 mL4.4777 mL
100 mM0.0448 mL0.2239 mL0.4478 mL2.2388 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Necroptosis-IN-3Necroptosis
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