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Amosulalol

Name: Amosulalol
Brand: TargetMol
SKU: T30027
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30027Cas No. 85320-68-9

Amosulalol is a combined alpha and beta adrenoceptor antagonist.

Amosulalol

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Purity: 99.5%

Catalog No. T30027Cas No. 85320-68-9

Amosulalol is a combined alpha and beta adrenoceptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
2 mg	$293	In Stock	In Stock
5 mg	$448	In Stock	In Stock
10 mg	$658	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,380	In Stock	In Stock
100 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$478	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.5%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Amosulalol AI Summary

Amosulalol exhibits beta-blocking activity with an activity level of 1.84 and demonstrates a diverse range of bioactivities in various assays. It inhibits human KCNH2 with an AC50 of 15,000 nM and shows significant binding affinity towards several receptors. Notably, it inhibits human ADRB1 with an AC50 of 60.0 nM, binds to human ADRB2 with an AC50 of 100.0 nM, and inhibits human ADRA1A with an AC50 of 300.0 nM. Other noteworthy activities include inhibition of human DRD2 (AC50 = 440.0 nM), human ADRA2C (AC50 = 2300.0 nM), human ADRA2B (AC50 = 6900.0 nM), and human PDE4D (AC50 = 6699.9 nM). Additionally, it shows binding affinity for human SLC6A4 (AC50 = 29,000.1 nM) and demonstrates both agonist and antagonist activities at various receptors, predominantly with AC50 values above 30,000.0 nM. These findings indicate that Amosulalol has significant capabilities in receptor binding, enzyme inhibition, and modulation of various receptor activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Amosulalol is a combined alpha and beta adrenoceptor antagonist.

Chemical Properties

Molecular Weight	380.46
Formula	C₁₈H₂₄N₂O₅S
Cas No.	85320-68-9
Smiles	S(N)(=O)(=O)C1=CC(C(CNCCOC2=C(OC)C=CC=C2)O)=CC=C1C
Relative Density.	1.268g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (118.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6284 mL	13.1420 mL	26.2840 mL	131.4199 mL
5 mM	0.5257 mL	2.6284 mL	5.2568 mL	26.2840 mL
10 mM	0.2628 mL	1.3142 mL	2.6284 mL	13.1420 mL
20 mM	0.1314 mL	0.6571 mL	1.3142 mL	6.5710 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6284 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3142 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc