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AMP-PNP tetralithium (Synonyms: Adenylyl-imidodiphosphate tetralithium)

Name: AMP-PNP tetralithium
Brand: TargetMol
SKU: T37733
Rating: 4.5 (1 reviews)

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AMP-PNP tetralithium（Adenylyl-imidodiphosphate tetralithium） is a non-hydrolyzable ATP analog that fully occupies ATP-binding sites without undergoing enzymatic hydrolysis, thereby providing stable and controlled experimental conditions for dissecting ATP-dependent biological processes. AMP-PNP is widely used to investigate enzyme activity, kinase regulation, DNA and RNA metabolism, ion channel function, and protein complex assembly in biochemical and structural biology studies.

AMP-PNP tetralithium

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Catalog No. T37733

Synonyms Adenylyl-imidodiphosphate tetralithium

Cas No. 72957-42-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$883	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	AMP-PNP tetralithium（Adenylyl-imidodiphosphate tetralithium） is a non-hydrolyzable ATP analog that fully occupies ATP-binding sites without undergoing enzymatic hydrolysis, thereby providing stable and controlled experimental conditions for dissecting ATP-dependent biological processes. AMP-PNP is widely used to investigate enzyme activity, kinase regulation, DNA and RNA metabolism, ion channel function, and protein complex assembly in biochemical and structural biology studies.
In vitro	In biochemical assays targeting the BtuCD-F ATPase, AMP-PNP tetralithium functioned as a competitive inhibitor with an IC50 ranging from 100 nM to 3.3 mM, effectively eluting the protein from ATP-agarose beads and suppressing enzymatic activity [4].
Synonyms	Adenylyl-imidodiphosphate tetralithium

Chemical Properties

Molecular Weight	529.93
Formula	C₁₀H₁₃Li₄N₆O₁₂P₃
Cas No.	72957-42-7
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Li+].[Li+].[Li+].[Li+]

Storage & Solubility Information

Storage

Store at low temperature | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (37.74 mM), onication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8870 mL	9.4352 mL	18.8704 mL	94.3521 mL
5 mM	0.3774 mL	1.8870 mL	3.7741 mL	18.8704 mL
10 mM	0.1887 mL	0.9435 mL	1.8870 mL	9.4352 mL
20 mM	0.0944 mL	0.4718 mL	0.9435 mL	4.7176 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AMP-PNP tetralithiumAMPPNP tetralithiumAMP-PNPAMP PNP tetralithium