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Ganoderic acid DM

Name: Ganoderic acid DM
Brand: TargetMol
SKU: TN1663
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1663 Copy Product Info

Purity: 99.98%

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Ganoderic acid DM is an antiandrogenic inhibitor of osteoclastogenesis that markedly suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). The suppression mediated by Ganoderic acid DM results in the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and a consequent reduction in osteoclast fusion. Ganoderic acid DM is therefore of considerable interest for mechanistic investigations involving osteoclast differentiation, bone remodeling, and androgen-associated signaling pathways in musculoskeletal research models.

Cas No. 173075-45-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$98	-	In Stock
5 mg	$289	-	In Stock
10 mg	$463	-	In Stock
25 mg	$747	-	In Stock
1 mL x 10 mM (in DMSO)	$298	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Ganoderic acid DM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. Ganoderic acid DM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we also showed that GADM elicited DNA damage as measured by comet assay which is a sensitive method for DNA damage detection. γ-H2AX, a marker of DNA damage, was also slightly up-regulated after treated with GADM for 6h, suggesting that the G1 cell cycle arrest and apoptosis induced by GADM may be partially resulted from GADM-induced DNA damage[1]

Chemical Properties

Molecular Weight	468.67
Formula	C₃₀H₄₄O₄
Cas No.	173075-45-1
Smiles	C[C@]12C3=C([C@]4(C)[C@@](CC3=O)(C(C)(C)C(=O)CC4)[H])CC[C@]1(C)[C@@]([C@@H](CC/C=C(/C(O)=O)\C)C)(CC2)[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (85.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1337 mL	10.6685 mL	21.3370 mL	106.6849 mL
5 mM	0.4267 mL	2.1337 mL	4.2674 mL	21.3370 mL
10 mM	0.2134 mL	1.0668 mL	2.1337 mL	10.6685 mL
20 mM	0.1067 mL	0.5334 mL	1.0668 mL	5.3342 mL
50 mM	0.0427 mL	0.2134 mL	0.4267 mL	2.1337 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc