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DOPEXAMINE

Name: DOPEXAMINE
Brand: TargetMol
SKU: T8653
Rating: 4.5 (1 reviews)

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Catalog No. T8653Cas No. 86197-47-9

Dopexamine is a dopaminergic agonist

DOPEXAMINE

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Catalog No. T8653Cas No. 86197-47-9

Dopexamine is a dopaminergic agonist

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	Inquiry	Inquiry
2 mg	$198	Inquiry	Inquiry
5 mg	$298	Inquiry	Inquiry
10 mg	$453	Inquiry	Inquiry
25 mg	$747	Inquiry	Inquiry
50 mg	$1,050	Inquiry	Inquiry
100 mg	$1,420	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$323	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Dopexamine is a dopaminergic agonist

In vivo

Dopexamine hydrochloride has interesting vasodilator properties, with marked intrinsic agonist activity at beta-2 adrenoreceptors and a lesser agonist activity at dopaminergic receptors (DA1 and DA2).?Dopexamine hydrochloride is responsible for an inhibition of neuronal re-uptake of catecholamines (uptake-1), producing an indirect stimulation of cardiac beta 1-receptors.?Dopexamine hydrochloride improves cardiac performance by a marked vasodilation and a mild inotropic activity.?The specific activity at dopaminergic receptors increases cerebral, myocardial, splanchnic and renal blood flows.?These haemodynamic effects are associated with an increase in diuresis and natriuresis.?These benefits are achieved without side effects such as an increased myocardial oxygen consumption, although induced tachycardia may be responsible for chest pain/anginae pain in patients with ischaemic heart disease[1].

Chemical Properties

Molecular Weight	356.5
Formula	C₂₂H₃₂N₂O₂
Cas No.	86197-47-9
Smiles	C(CNCCCCCCNCCC1=CC=CC=C1)C2=CC(O)=C(O)C=C2
Relative Density.	1.081 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (154.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8050 mL	14.0252 mL	28.0505 mL	140.2525 mL
5 mM	0.5610 mL	2.8050 mL	5.6101 mL	28.0505 mL
10 mM	0.2805 mL	1.4025 mL	2.8050 mL	14.0252 mL
20 mM	0.1403 mL	0.7013 mL	1.4025 mL	7.0126 mL
50 mM	0.0561 mL	0.2805 mL	0.5610 mL	2.8050 mL
100 mM	0.0281 mL	0.1403 mL	0.2805 mL	1.4025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc