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Bay 41-4109

Name: Bay 41-4109
Brand: TargetMol
SKU: T10480L
Rating: 4.5 (1 reviews)

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Catalog No. T10480LCas No. 298708-81-3

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

Bay 41-4109

😃Good

Catalog No. T10480LCas No. 298708-81-3

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$386	5 days	5 days
25 mg	$2,270	6-8 weeks	6-8 weeks
50 mg	$2,980	6-8 weeks	6-8 weeks
100 mg	$4,180	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
Targets&IC50	HBV:53 nM
In vitro	BAY 41-4109 effectively accelerates and alters the direction of capsid assembly in vitro, demonstrating potent inhibitory effects on both HBV DNA release and cytoplasmic HBcAg levels, with IC50 values of 32.6 and 132 nM in HepG2.2.15 cells, respectively. Its inhibitory action on HBV DNA and HBcAg is dose-dependent, underscoring that its anti-HBV properties hinge on the rate at which HBcAg is inhibited. Additionally, BAY 41-4109 can stabilize preformed capsids, achieving a stabilization ratio of one inhibitor molecule per two dimers.
In vivo	BAY 41-4109 effectively suppresses virus production in vivo through a mechanism focusing on the viral capsid[2]. It dose-dependently decreases viral DNA in both the liver and plasma, showing efficacy on par with 3TC, and it diminishes hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic evaluations in mice reveal quick absorption, 30% bioavailability, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs[1].

Chemical Properties

Molecular Weight	395.76
Formula	C₁₈H₁₃ClF₃N₃O₂
Cas No.	298708-81-3
Smiles	COC(=O)C1=C(C)N=C(N[C@H]1c1ccc(F)cc1Cl)c1ncc(F)cc1F
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (252.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5268 mL	12.6339 mL	25.2678 mL	126.3392 mL
5 mM	0.5054 mL	2.5268 mL	5.0536 mL	25.2678 mL
10 mM	0.2527 mL	1.2634 mL	2.5268 mL	12.6339 mL
20 mM	0.1263 mL	0.6317 mL	1.2634 mL	6.3170 mL
50 mM	0.0505 mL	0.2527 mL	0.5054 mL	2.5268 mL
100 mM	0.0253 mL	0.1263 mL	0.2527 mL	1.2634 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc