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5-Hydroxypropafenone hydrochloride
🥰Excellent
Catalog No. T207763Cas No. 86383-32-6
Alias Lu 40545
5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC50 of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.
5-Hydroxypropafenone hydrochloride
🥰Excellent
Catalog No. T207763Alias Lu 40545Cas No. 86383-32-6
5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC50 of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC50 of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg. |
| Synonyms | Lu 40545 |
| Molecular Weight | 393.90 |
| Formula | C21H28ClNO4 |
| Cas No. | 86383-32-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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