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Anticancer agent 299
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Catalog No. T218223 Copy Product Info
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Anticanceragent 299 (compound P12) acts as a cell cycle inhibitor, senescence inducer, apoptosis inducer, and antiproliferative agent. It exhibits selective activity against cancer cells while having minimal impact on non-tumor chondrocytes at relevant concentrations. Anticanceragent 299 is applicable in research on ER+/HER2− breast cancer and BRAF-mutant melanoma.
Anticancer agent 299
Cas No. 1414873-26-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anticanceragent 299 (compound P12) acts as a cell cycle inhibitor, senescence inducer, apoptosis inducer, and antiproliferative agent. It exhibits selective activity against cancer cells while having minimal impact on non-tumor chondrocytes at relevant concentrations. Anticanceragent 299 is applicable in research on ER+/HER2− breast cancer and BRAF-mutant melanoma. |
| In vitro | Anticancer agent 299 (P12) at concentrations of 5-50 μM, with a treatment duration of 7 days, reduces colony formation in MCF7 and A375 cells, with IC50 values of 30.22 μM and 2.915 μM, respectively, and has minimal effects on non-tumor TC28a2 cells at 5-35 μM. At 5 μM, it decreases the spheroid size of MCF7 cells after 8 and 12 days, and A375 cells after 4 days of treatment. Over 7 days, it reduces the G2/M phase cell population to 15.65% in MCF7 and 1.94% in A375 cells. Moreover, it upregulates G1/S and S phase-related genes in MCF7 cells while downregulating these genes in A375 cells, and induces the expression of senescence-associated genes (p21, p53, IGFBP3, GDF15) in both cell lines. In MCF7 cells, it increases the expression of SASP factors (IL-6, IL-8), with no such effect observed in A375. Additionally, treatment for 4 days or longer induces early apoptosis in MCF7 and A375 cells. |
| Molecular Weight | 435.44 |
| Formula | C25H20F3N3O |
| Cas No. | 1414873-26-9 |
| Smiles | FC(F)(F)C=1C=CC(=CC1)C2=NC(=NC(=C2)C=3C=CC=C4C=CC=CC43)N5CCOCC5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Anticancer agent 299 in vitro | Anticancer agent 299 formula | Anticancer agent 299 molecular weight
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