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Romosozumab
🥰Excellent
Catalog No. T77380Cas No. 909395-70-6
Alias CDP-7851, CDP7851, AMG-785, AMG785
Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption.Romosozumab is used in the study of postmenopausal osteoporosis.
Romosozumab
Romosozumab
🥰Excellent
Purity: 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)
Catalog No. T77380Alias CDP-7851, CDP7851, AMG-785, AMG785Cas No. 909395-70-6
Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption.Romosozumab is used in the study of postmenopausal osteoporosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $232 | In Stock | |
| 5 mg | $581 | In Stock | |
| 10 mg | $930 | In Stock | |
| 25 mg | $1,581 | In Stock | |
| 50 mg | $2,370 | In Stock |
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Concentration:6.15 mg/mL
Purity:98.9% (SDS-PAGE); 98.2% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption.Romosozumab is used in the study of postmenopausal osteoporosis. |
| In vivo | Romosozumab (30 mg/kg twice weekly for 10 weeks) induces the transformation of bone trabecular rod-like structures to plate-like structures in cynomolgus monkeys. [1] In mature cynomolgus monkeys undergoing ovariectomy for 4 months, Romosozumab (3 mg/kg and 30 mg/kg once weekly for 6 or 12 months) was able to enhance bone mass, optimize bone structure, and improve bone strength while maintaining bone quality. [2] |
| Synonyms | CDP-7851, CDP7851, AMG-785, AMG785 |
| Cas No. | 909395-70-6 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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