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Romosozumab
(Synonyms: CDP-7851, CDP7851, AMG-785, AMG785) Copy Product Info
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Synonyms: CDP-7851, CDP7851, AMG-785, AMG785
Catalog No. T77380 Copy Product Info
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Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption.Romosozumab is used in the study of postmenopausal osteoporosis.
Romosozumab
Cas No. 909395-70-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $232 | - | In Stock | |
| 5 mg | $581 | - | In Stock | |
| 10 mg | $930 | - | In Stock | |
| 25 mg | $1,581 | - | In Stock | |
| 50 mg | $2,370 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.9% (SDS-PAGE); 98.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption.Romosozumab is used in the study of postmenopausal osteoporosis. |
| In vivo | Romosozumab (30 mg/kg twice weekly for 10 weeks) induces the transformation of bone trabecular rod-like structures to plate-like structures in cynomolgus monkeys. [1] In mature cynomolgus monkeys undergoing ovariectomy for 4 months, Romosozumab (3 mg/kg and 30 mg/kg once weekly for 6 or 12 months) was able to enhance bone mass, optimize bone structure, and improve bone strength while maintaining bone quality. [2] |
| Synonyms | CDP-7851, CDP7851, AMG-785, AMG785 |
| Reactivity | Human |
| Verified Activity | Immobilized Human SOST Protein (His) (TMPY-00925) at 1 μg/mL (100 μL/well) can bind Romosozumab. The EC50 is 16.42 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | SOST/Sclerostin |
| Molecular Weight | 145.87 kDa |
| Cas No. | 909395-70-6 |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Romosozumab in vivo | Romosozumab molecular weight
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