Benalfocin hydrochloride

Name: Benalfocin hydrochloride
Brand: TargetMol
SKU: T23366
Rating: 4.5 (1 reviews)

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Catalog No. T23366Cas No. 86129-54-6

Alias SKF86466 hydrochloride, SKF 86466 hydrochloride

Benalfocin hydrochloride is a potent and selective α2-adrenergic receptor antagonist that blocks α2A, α2B, and α2C receptor subtypes with high affinity, Benalfocin hydrochloride is widely employed in neuroscience research to dissect adrenergic signaling pathways by inhibiting adrenaline-mediated effects on neurotransmission, autonomic regulation, and central nervous system function.

Benalfocin hydrochloride

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Catalog No. T23366Alias SKF86466 hydrochloride, SKF 86466 hydrochlorideCas No. 86129-54-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	35 days	35 days
5 mg	$395	35 days	35 days
10 mg	$555	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Benalfocin hydrochloride is a potent and selective α2-adrenergic receptor antagonist that blocks α2A, α2B, and α2C receptor subtypes with high affinity, Benalfocin hydrochloride is widely employed in neuroscience research to dissect adrenergic signaling pathways by inhibiting adrenaline-mediated effects on neurotransmission, autonomic regulation, and central nervous system function.
In vitro	At a concentration of 10 μM (1 hour incubation), Benalfocin hydrochloride induces the threonine phosphorylation of DARPP-32, a 32 kDa dopamine- and cAMP-regulated phosphoprotein [2].
In vivo	In mouse models treated with the neurotoxin MPTP, Benalfocin hydrochloride (10 mg/kg, i.p.) exhibits neuroprotective effects. Administration of the molecule blocks the depletion of glutathione and attenuates the reduction of dopamine levels. It also increases the activity of superoxide dismutase (SOD), showing antioxidant properties in the brain. In hippocampal studies, Benalfocin hydrochloride stimulates glutamate release by acting on presynaptic D1 receptors [3][4].
Synonyms	SKF86466 hydrochloride, SKF 86466 hydrochloride

Chemical Properties

Molecular Weight	232.15
Formula	C₁₁H₁₅Cl₂N
Cas No.	86129-54-6
Smiles	Cl.ClC1=CC=CC2=C1CCN(C)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage	In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc