2',3'-cGAMP

Name: 2',3'-cGAMP
Brand: TargetMol
SKU: T10065
Price: 247 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10065Cas No. 1441190-66-4

Alias Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMP

2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.

2',3'-cGAMP

🥰Excellent

Catalog No. T10065Alias Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMPCas No. 1441190-66-4

Pack Size	Price	Availability	Quantity
1 mg	$247	In Stock

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Product Introduction

Bioactivity

Description	2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.
Targets&IC50	STING:3.79 nM(Kd)
In vitro	2',3'-cGAMP contains two distinct phosphodiester bonds: one linking the 2'-hydroxyl group of GMP with the 5'-phosphate of AMP, and another connecting the 3'-hydroxyl group of AMP with the 5'-phosphate of GMP [1].
Synonyms	Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMP

Chemical Properties

Molecular Weight	674.41
Formula	C₂₀H₂₄N₁₀O₁₃P₂
Cas No.	1441190-66-4
Smiles	O[C@H]1[C@@]2([C@@H](O[C@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@H]([C@@H]3O)N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])N6C7=C(N=C6)C(=O)N=C(N)N7)[H]
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: ≥ 40 mg/mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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