Shopping Cart

Your shopping cart is currently empty

TOMATIDINE HYDROCHLORIDE

Name: TOMATIDINE HYDROCHLORIDE
Brand: TargetMol
SKU: T4592
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4592Cas No. 6192-62-7

Alias Tomatidine HCl

Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.

TOMATIDINE HYDROCHLORIDE

Copy Product Info

🥰Excellent

Purity: 99.94%

Catalog No. T4592Alias Tomatidine HClCas No. 6192-62-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$42	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$92	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.94%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

TOMATIDINE HYDROCHLORIDE AI Summary

TOMATIDINE HYDROCHLORIDE exhibits various bioactivities, most notably as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 16360.1 nM, determined through a quantitative high-throughput screening (qHTS) assay conducted in the absence of camptothecin. It strongly inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells at a 10 μM concentration, with inhibition rates of 108.76% and 99.59%, respectively. The compound demonstrates antimicrobial activity against Staphylococcus aureus ATCC 29213 with a MIC greater than 64.0 μg/mL and synergizes with gentamicin (FICI of 8.0). It is highly effective against hemB-deficient Staphylococcus aureus Newbould, showing an MIC of 0.06 μg/mL. Antifungal properties include a MIC of 20000.0 nM against Candida albicans, although it shows no significant activity against Cryptococcus neoformans or a range of bacteria, including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Additionally, TOMATIDINE HYDROCHLORIDE has low hemolytic activity on human red blood cells at concentrations above 20.0 μM and shows low cytotoxicity against HEK293 cells (CC50 > 20000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.
Synonyms	Tomatidine HCl

Chemical Properties

Molecular Weight	452.11
Formula	C₂₇H₄₆ClNO₂
Cas No.	6192-62-7
Smiles	C[C@@H]1[C@@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@@](CC5)(C[C@@H](O)CC6)[H])[H])[H])[H])[H])[H])CC[C@H](C)CN2.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 12.5 mg/mL (27.65 mM), Sonication is recommended.

DMSO: 1.67 mg/mL (3.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	2.2119 mL	11.0593 mL	22.1185 mL	110.5926 mL

Methanol

	1mg	5mg	10mg	50mg
5 mM	0.4424 mL	2.2119 mL	4.4237 mL	22.1185 mL
10 mM	0.2212 mL	1.1059 mL	2.2119 mL	11.0593 mL
20 mM	0.1106 mL	0.5530 mL	1.1059 mL	5.5296 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc