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Mirin
🥰Excellent
Catalog No. T60273Cas No. 299953-00-7
Alias 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
Mirin
🥰Excellent
Purity: 99.24%
Catalog No. T60273Alias 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-oneCas No. 299953-00-7
Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $40 | In Stock | |
| 10 mg | $65 | In Stock | |
| 25 mg | $121 | In Stock | |
| 50 mg | $180 | In Stock | |
| 100 mg | $265 | In Stock | |
| 200 mg | $392 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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Purity:99.24%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase. |
| In vitro | Mirin inhibits H2AX phosphorylation with an IC50 value of 66 μM. Mirin inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2 as well as MRN-dependent ATM autophosphorylation at Ser1981 in response to DSBs. Mirin treatment (50, 100 μM) of TOSA4 cells induced a significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells. [1] |
| Synonyms | 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one |
| Molecular Weight | 220.25 |
| Formula | C10H8N2O2S |
| Cas No. | 299953-00-7 |
| Smiles | O=C1N=C(SC1=CC2=CC=C(O)C=C2)N |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMF: 60 mg/mL (272.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMF
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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