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Mirin

Name: Mirin
Brand: TargetMol
SKU: T60273
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one) Copy Product Info

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Synonyms: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

Catalog No. T60273 Copy Product Info

Purity: 99.24%

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Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.

Cas No. 299953-00-7

Pack Size	Price	USA Stock	Global Stock
2 mg	$30	In Stock	In Stock
5 mg	$40	In Stock	In Stock
10 mg	$65	In Stock	In Stock
25 mg	$121	-	In Stock
50 mg	$180	-	In Stock
100 mg	$265	-	In Stock
200 mg	$392	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.24%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
In vitro	Mirin inhibits H2AX phosphorylation with an IC50 value of 66 μM. Mirin inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2 as well as MRN-dependent ATM autophosphorylation at Ser1981 in response to DSBs. Mirin treatment (50, 100 μM) of TOSA4 cells induced a significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells. [1]
Synonyms	5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

Chemical Properties

Molecular Weight	220.25
Formula	C₁₀H₈N₂O₂S
Cas No.	299953-00-7
Smiles	O=C1N=C(SC1=CC2=CC=C(O)C=C2)N

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (378.21 mM), Sonication is recommended.

DMF: 60 mg/mL (272.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8.33 mg/mL (37.82 mM), Solution.

10% DMSO+90% Saline: < 8.33 mg/mL (37.82 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5403 mL	22.7015 mL	45.4030 mL	227.0148 mL
5 mM	0.9081 mL	4.5403 mL	9.0806 mL	45.4030 mL
10 mM	0.4540 mL	2.2701 mL	4.5403 mL	22.7015 mL
20 mM	0.2270 mL	1.1351 mL	2.2701 mL	11.3507 mL
50 mM	0.0908 mL	0.4540 mL	0.9081 mL	4.5403 mL
100 mM	0.0454 mL	0.2270 mL	0.4540 mL	2.2701 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Mirin chemical structure | Mirin in vitro | Mirin formula | Mirin molecular weight