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Oxyphenonium bromide

Name: Oxyphenonium bromide
Brand: TargetMol
SKU: T33846
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T33846Cas No. 50-10-2

Alias Spasmophen, Oxyphenon, Oxyfenon, Oxifenon, Atrenyl

Oxyphenonium bromide (Oxyfenon) shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms.

Oxyphenonium bromide

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🥰Excellent

Purity: 98.96%

Catalog No. T33846Alias Spasmophen, Oxyphenon, Oxyfenon, Oxifenon, AtrenylCas No. 50-10-2

Oxyphenonium bromide (Oxyfenon) shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$62	In Stock	In Stock
50 mg	$91	In Stock	In Stock
100 mg	$133	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Oxyphenonium bromide AI Summary

Oxyphenonium bromide exhibits diverse bioactivities across various biological assays. It demonstrates significant potency in multiple quantitative high-throughput screening (qHTS) assays, including 730.8 nM for lipid storage modulators in Drosophila S3 cells, 1122.0 nM for inhibitors of cell surface uPA generation, 281.8 nM for TGF-b inhibitors, and 1258.9 nM for DNA re-replication in SW480 colon adenocarcinoma cells. Additionally, it shows varied potencies in primary qHTS assays for delayed death inhibitors of the malarial parasite plastid (11689.1 nM and 13115.4 nM), Nrf2 inhibitors (ranging from 7307.8 nM to 18356.4 nM), HP1-beta chromodomain interactions inhibitors (112201.8 nM), and inhibitors of Pin1 (44668.4 nM). Moreover, Oxyphenonium bromide displays antiviral activities, including inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (1.46% inhibition at 10 µM) and VERO-6 cells (0.37% inhibition at 10 µM). It also acts as a SARS-CoV-2 3CL-Pro protease inhibitor with a 9.003% inhibition at 20 µM, as determined by a FRET assay. Furthermore, it exhibits an AC50 of 7.943 µM for blocking Ebola Virus entry. In terms of antibacterial and antifungal activities, Oxyphenonium bromide inhibits various strains including Escherichia coli (3.27% inhibition), Klebsiella pneumoniae (20.0% inhibition), Pseudomonas aeruginosa (14.05% inhibition), Acinetobacter baumannii (27.96% inhibition), and Staphylococcus aureus MRSA (12.65% inhibition). It also demonstrates antifungal activity against Candida albicans with 2.42% inhibition, while showing negative inhibition against Cryptococcus neoformans (-6.44%), indicating lack of activity or possible stimulation. Overall, Oxyphenonium bromide's bioactivities encompass inhibiting lipid storage, various enzymes, viral entry, and exhibiting antibacterial and antifungal effects, highlighting its broad-spectrum potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxyphenonium bromide (Oxyfenon) shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms.
Synonyms	Spasmophen, Oxyphenon, Oxyfenon, Oxifenon, Atrenyl

Chemical Properties

Molecular Weight	428.404
Formula	C₂₁H₃₄BrNO₃
Cas No.	50-10-2
Smiles	[Br-].CC[N+](C)(CC)CCOC(=O)C(O)(C1CCCCC1)c1ccccc1
Relative Density.	1.2584 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (64.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3342 mL	11.6712 mL	23.3425 mL	116.7123 mL
5 mM	0.4668 mL	2.3342 mL	4.6685 mL	23.3425 mL
10 mM	0.2334 mL	1.1671 mL	2.3342 mL	11.6712 mL
20 mM	0.1167 mL	0.5836 mL	1.1671 mL	5.8356 mL
50 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3342 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc