Arzoxifene hydrochloride

Name: Arzoxifene hydrochloride
Brand: TargetMol
SKU: T10379
Rating: 4.5 (1 reviews)

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Catalog No. T10379Cas No. 182133-27-3

Alias SERM 3, LY 353381 HCl

Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.

Arzoxifene hydrochloride

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Catalog No. T10379Alias SERM 3, LY 353381 HClCas No. 182133-27-3

Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,120	8-10 weeks	8-10 weeks
50 mg	$2,780	8-10 weeks	8-10 weeks
100 mg	$3,700	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.
In vitro	Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen, demonstrating statistically significant inhibition of pS2 and progesterone receptor B mRNA expression along with a significant agonistic effect on antitrypsin mRNA expression. Unlike estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.
In vivo	Arzoxifene counteracts the ovariectomy-induced increase in body weight and serum cholesterol in treated rats, effectively reducing them below sham levels in a dose-dependent manner, with maximum efficacy comparable to estrogen or raloxifene. It prevents bone loss due to ovariectomy, showing maximal efficacy at 0.1-1 mg/kg/day [ED50: approximately 0.01 mg/kg]. Additionally, arzoxifene mitigates the estrogen-induced rise in uterine weight to vehicle-dosed control levels [ED50: 0.03 mg/kg/day].
Synonyms	SERM 3, LY 353381 HCl

Chemical Properties

Molecular Weight	512.06
Formula	C₂₈H₃₀ClNO₄S
Cas No.	182133-27-3
Smiles	Cl.COc1ccc(cc1)-c1sc2cc(O)ccc2c1Oc1ccc(OCCN2CCCCC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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