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Peruvoside

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Catalog No. T126270Cas No. 1182-87-2
Alias Encordin

Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .

Peruvoside

Peruvoside

😃Good
Catalog No. T126270Alias EncordinCas No. 1182-87-2
Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
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1 mg$328 7-10 days
5 mg$778 7-10 days
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Product Introduction

Bioactivity
Description
Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
In vitro
Methods: A549 lung cancer cell line was treated with Peruvoside (5, 10, 50 nM, 24 hours), and the expression of related proteins was analyzed by Western Blot.
Results: Peruvoside inhibited the protein expression and phosphorylation of Src, EGFR and STAT3 in A549 cells. [1]
In vivo
Methods: Nude mice with A549 cell subcutaneous xenografts were treated with Peruvoside (0.1 mg/kg, intraperitoneal injection, daily, for 28 days). Tumor growth was then monitored every 7 days.
Results: The mean tumor size in the Peruvoside-treated group was 129.9 mm³ (95% CI = 86-174 mm³; P = 0.0068), which was significantly smaller than that in the control group (348 mm³, 95% CI = 189-507 mm³). The tumor weight was also significantly reduced, from 0.55 g in the control group to 0.26 g in the Peruvoside-treated group (P = 0.0126). [1]
AliasEncordin
Chemical Properties
Molecular Weight548.673
FormulaC30H44O9
Cas No.1182-87-2
Smiles[H][C@]12CCC3C(CC[C@]4(C)[C@H](CC[C@]34O)C3=CC(=O)OC3)[C@]1(CC[C@@H](C2)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](OC)[C@@H]1O)C=O
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (364.52 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8226 mL9.1129 mL18.2258 mL91.1290 mL
5 mM0.3645 mL1.8226 mL3.6452 mL18.2258 mL
10 mM0.1823 mL0.9113 mL1.8226 mL9.1129 mL
20 mM0.0911 mL0.4556 mL0.9113 mL4.5564 mL
50 mM0.0365 mL0.1823 mL0.3645 mL1.8226 mL
100 mM0.0182 mL0.0911 mL0.1823 mL0.9113 mL

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