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Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $328 | 7-10 days | |
5 mg | $778 | 7-10 days |
Description | Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR . |
In vitro | Methods: A549 lung cancer cell line was treated with Peruvoside (5, 10, 50 nM, 24 hours), and the expression of related proteins was analyzed by Western Blot. Results: Peruvoside inhibited the protein expression and phosphorylation of Src, EGFR and STAT3 in A549 cells. [1] |
In vivo | Methods: Nude mice with A549 cell subcutaneous xenografts were treated with Peruvoside (0.1 mg/kg, intraperitoneal injection, daily, for 28 days). Tumor growth was then monitored every 7 days. Results: The mean tumor size in the Peruvoside-treated group was 129.9 mm³ (95% CI = 86-174 mm³; P = 0.0068), which was significantly smaller than that in the control group (348 mm³, 95% CI = 189-507 mm³). The tumor weight was also significantly reduced, from 0.55 g in the control group to 0.26 g in the Peruvoside-treated group (P = 0.0126). [1] |
Alias | Encordin |
Molecular Weight | 548.67 |
Formula | C30H44O9 |
Cas No. | 1182-87-2 |
Smiles | C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@@]1(C[C@@H](O[C@H]6[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O6)CC2)[H])[H])[H] |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200.00 mg/mL (364.52 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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