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Enerisant hydrochloride

Name: Enerisant hydrochloride
Brand: TargetMol
SKU: T70489
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T70489Cas No. 1152749-07-9

Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

Enerisant hydrochloride

🥰Excellent

Purity: 99.30%

Catalog No. T70489Cas No. 1152749-07-9

Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$227	In Stock
10 mg	$365	In Stock
25 mg	$592	In Stock
50 mg	$857	In Stock
100 mg	$1,150	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.30%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

In vivo

Enerisant HCl (0.3-1 mg/kg; p.o.; once; Male SD rats) attenuates the biphagous response in rats.[1]
Enerisant hydrochloride (0.1-3 mg/kg; p.o.; once; Male SD rats) causes histamine H3 receptor occupancy in a dose-dependent manner in rats. The dose causing half-maximal receptor occupancy was 0.78 mg/kg.[1]
Enerisant HCl (1 mg/kg; s.c.; once; Male SD rats) increases total extracellular histamine levels in the posterior hypothalamus of rats.[1]
Enerisant HCl (1 mg/kg; i.p.; once; Male SD rats) increases total extracellular dopamine and acetylcholine levels in the rat medial prefrontal cortex (mPFC).[1]

Chemical Properties

Molecular Weight	434.96
Formula	C₂₂H₃₁ClN₄O₃
Cas No.	1152749-07-9
Smiles	C(=O)(C1=CN(N=C1)C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)N4CCOCC4.Cl
Color	White
Appearance	Oil

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2991 mL	11.4953 mL	22.9906 mL	114.9531 mL
5 mM	0.4598 mL	2.2991 mL	4.5981 mL	22.9906 mL
10 mM	0.2299 mL	1.1495 mL	2.2991 mL	11.4953 mL
20 mM	0.1150 mL	0.5748 mL	1.1495 mL	5.7477 mL
50 mM	0.0460 mL	0.2299 mL	0.4598 mL	2.2991 mL
100 mM	0.0230 mL	0.1150 mL	0.2299 mL	1.1495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc