Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 430.00 | |
10 mg | In stock | $ 636.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,360.00 | |
100 mg | In stock | $ 1,830.00 |
Description | Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins. |
In vivo |
Enerisant HCl (0.3-1 mg/kg; p.o.; once; Male SD rats) attenuates the biphagous response in rats.[1] Enerisant hydrochloride (0.1-3 mg/kg; p.o.; once; Male SD rats) causes histamine H3 receptor occupancy in a dose-dependent manner in rats. The dose causing half-maximal receptor occupancy was 0.78 mg/kg.[1] Enerisant HCl (1 mg/kg; s.c.; once; Male SD rats) increases total extracellular histamine levels in the posterior hypothalamus of rats.[1] Enerisant HCl (1 mg/kg; i.p.; once; Male SD rats) increases total extracellular dopamine and acetylcholine levels in the rat medial prefrontal cortex (mPFC).[1] |
Molecular Weight | 434.96 |
Formula | C22H31ClN4O3 |
CAS No. | 1152749-07-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (114.95 mM)
You can also refer to dose conversion for different animals. More
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Enerisant HCl 1152749-07-9 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience P450 Histamine Receptor QD 232 QD-232 inhibitor inhibit