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Dentonin

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Catalog No. T40498Cas No. 400090-20-2
Alias AC-100

Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells, without significantly affecting mature osteoblasts. Dentonin is valuable for research on phosphate homeostasis and bone metabolism.

Dentonin
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Dentonin

😃Good
Catalog No. T40498Alias AC-100Cas No. 400090-20-2
Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells, without significantly affecting mature osteoblasts. Dentonin is valuable for research on phosphate homeostasis and bone metabolism.
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Product Introduction

Bioactivity
Description
Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells, without significantly affecting mature osteoblasts. Dentonin is valuable for research on phosphate homeostasis and bone metabolism.
In vitro
MEPE, a secreted glycophosphoprotein belonging to the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family, plays a crucial role in regulating bone mass and osteoblast activity. Dentonin, at concentrations of 3-30 μg/ml over 2-24 hours, significantly enhances cell proliferation and promotes cell adhesion, though it does not affect the overall number of cells adhered. Additionally, Dentonin markedly increases osteoblast spreading, demonstrating significantly larger cell areas compared to other treatments.
SynonymsAC-100
Chemical Properties
Molecular Weight2538.625
FormulaC107H160N30O42
Cas No.400090-20-2
SmilesCC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(O)=O
SequenceThr-Asp-Leu-Gln-Glu-Arg-Gly-Asp-Asn-Asp-Ile-Ser-Pro-Phe-Ser-Gly-Asp-Gly-Gln-Pro-Phe-Lys-Asp
Sequence ShortTDLQERGDNDISPFSGDGQPFKD
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

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Keywords

DentoninAC100AC 100
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