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VNT-101

Name: VNT-101
Brand: TargetMol
SKU: T212391
Price: 176 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: VNT101, VNT 101) Copy Product Info

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Synonyms: VNT101, VNT 101

Catalog No. T212391 Copy Product Info

Purity: 99.73%

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VNT-101 is an orally active influenza A virus (IAV) inhibitor with potent antiviral activity against multiple influenza A virus subtypes.

Cas No. 2894060-67-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$176	-	In Stock
5 mg	$388	-	In Stock
10 mg	$622	-	In Stock
25 mg	$1,240	-	In Stock
1 mL x 10 mM (in DMSO)	$390	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.73%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	VNT-101 is an orally active influenza A virus (IAV) inhibitor with potent antiviral activity against multiple influenza A virus subtypes.
Targets & IC50	H3N2/Alaska:21 nM(EC50), H1N1/PR8:8 nM(EC50), H1N1/PR8:5 nM(EC50), H3N2/Alaska:4 nM(EC50)
In vitro	VNT-101 demonstrated potent antiviral activity against influenza A viruses in RNP assays, with an EC50 of 45 nM against the H1N1/California subtype and 21 nM against the H3N2/Alaska subtype. In NA assays, VNT-101 exhibited potent inhibition of viral neuraminidase, with an EC50 of 8 nM against the H1N1/PR8 subtype and 4 nM against the H3N2/Alaska subtype. In CPE assays, VNT-101 effectively inhibited virus-induced cytopathic effects, with an EC50 of 5 nM against the H1N1/PR8 subtype and 4 nM against the H3N2/Alaska subtype [1].
In vivo	VNT-101 (1-30 mg/kg, administered orally twice daily for 5 days) exhibits anti-influenza activity in Balb/c mice infected with the H1N1 virus.
Synonyms	VNT101, VNT 101

Chemical Properties

Molecular Weight	456.41
Formula	C₂₁H₂₃F₃N₂O₆
Cas No.	2894060-67-2
Smiles	C(F)(F)(F)C1=C(C=C(C(N)=O)C(=O)N1)C2=CC=C(OC[C@H]3O[C@](COC)(C)COC3)C=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (175.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1910 mL	10.9551 mL	21.9101 mL	109.5506 mL
5 mM	0.4382 mL	2.1910 mL	4.3820 mL	21.9101 mL
10 mM	0.2191 mL	1.0955 mL	2.1910 mL	10.9551 mL
20 mM	0.1096 mL	0.5478 mL	1.0955 mL	5.4775 mL
50 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1910 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	1.0955 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: VNT-101 chemical structure | VNT-101 in vivo | VNT-101 in vitro | VNT-101 formula | VNT-101 molecular weight