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Endosidin-2

Catalog No. T37020 CAS 1839524-44-5

Synonyms: ES2, Endosidin 2

Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.

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Endosidin-2, CAS 1839524-44-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 322.00
100 mg	In stock	$ 538.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 98.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
Targets&IC50	Polarized cells:8.8 -12.3 µM
In vitro	Endosidin2 (ES2) was utilized in studying polarized cell growth in the moss Physcomitrium patens , in which plants were exposed to increasing concentrations of ES2 with an IC50 between 8.8 and 12.3 µM. At 50 µM, tip-growing cells ruptured close to their tips, an indication that ES2 inhibits the deposition of new cell wall material via exocytosis.[2]

Synonyms	ES2, Endosidin 2
Molecular Weight	414.17
Formula	C15H12FIN2O3
CAS No.	1839524-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (217.3 mM), Sonication is recommended.

DMF: 30 mg/mL

Ethanol: 0.25 mg/mL

References and Literature

1. Zhang C, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016;113(1):E41-E50. 2. Bormann E, et al. Inhibition of the Exocyst Complex with Endosidin 2 Reduces Polarized Growth in Physcomitrium patens. MicroPubl Biol. 2022;2022:10.17912/micropub.biology.000655.

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Keywords

Endosidin-2 1839524-44-5 ES2 ES-2 Endosidin 2 ES 2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.