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Stachydrine

Name: Stachydrine
Brand: TargetMol
SKU: T5769
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5769Cas No. 471-87-4

Alias Proline betaine, N,N-Dimethyl-L-proline, Methyl hygrate betaine, L-stachydrine

Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.

Stachydrine

🥰Excellent

Purity: 99.94%

Catalog No. T5769Alias Proline betaine, N,N-Dimethyl-L-proline, Methyl hygrate betaine, L-stachydrineCas No. 471-87-4

Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$48	In Stock
25 mg	$75	In Stock
50 mg	$101	In Stock
100 mg	$140	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock

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Purity:99.94%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.
In vitro	Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05).
Cell Research	Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot.
Synonyms	Proline betaine, N,N-Dimethyl-L-proline, Methyl hygrate betaine, L-stachydrine

Chemical Properties

Molecular Weight	143.18
Formula	C₇H₁₃NO₂
Cas No.	471-87-4
Smiles	C[N+]1(C)CCC[C@H]1C([O-])=O
Relative Density.	1.1095 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 26 mg/mL (181.59 mM), Sonication is recommended.

H2O: 32 mg/mL (223.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.9842 mL	34.9211 mL	69.8422 mL	349.2108 mL
5 mM	1.3968 mL	6.9842 mL	13.9684 mL	69.8422 mL
10 mM	0.6984 mL	3.4921 mL	6.9842 mL	34.9211 mL
20 mM	0.3492 mL	1.7461 mL	3.4921 mL	17.4605 mL
50 mM	0.1397 mL	0.6984 mL	1.3968 mL	6.9842 mL
100 mM	0.0698 mL	0.3492 mL	0.6984 mL	3.4921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc