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Hydroxystilbamidine

Catalog No. T9879Cas No. 495-99-8
Alias Oxistilbamidinum, Bis(8-hydroxyquinolinium) sulphate, 2-Hydroxy-4,4'-diguanylstilbene, (E)-hydroxystilbamidine

Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.

Hydroxystilbamidine

Hydroxystilbamidine

Purity: 98.3%
Catalog No. T9879Alias Oxistilbamidinum, Bis(8-hydroxyquinolinium) sulphate, 2-Hydroxy-4,4'-diguanylstilbene, (E)-hydroxystilbamidineCas No. 495-99-8
Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
2 mg$293In Stock
5 mg$447In Stock
10 mg$659In Stock
25 mg$987In Stock
50 mg$1,380In Stock
100 mg$1,890In Stock
500 mg$3,790In Stock
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Purity:98.3%
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Product Introduction

Bioactivity
Description
Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.
In vitro
Hydroxystilbamidine permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine is present before the addition of NP-40[1].
In vivo
Hydroxystilbamidine is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine treated mice and the control group is essentially at the background level[2].
AliasOxistilbamidinum, Bis(8-hydroxyquinolinium) sulphate, 2-Hydroxy-4,4'-diguanylstilbene, (E)-hydroxystilbamidine
Chemical Properties
Molecular Weight280.32
FormulaC16H16N4O
Cas No.495-99-8
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Insoluble

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Hydroxystilbamidine
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