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Isolithocholic Acid

Catalog No. T35792 CAS 1534-35-6

Synonyms: 3-Epilithocholic acid, 3β-Hydroxy-5β-cholanic acid, β-Lithocholic acid, isoLCA

Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.

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Isolithocholic Acid, CAS 1534-35-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 372.00
10 mg	In stock	$ 549.00
25 mg	In stock	$ 869.00
50 mg	In stock	$ 1,170.00
100 mg	In stock	$ 1,580.00
500 mg	In stock	$ 3,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 99.65%

Purity: 99.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
In vitro	Isolithocholic Acid at a concentration of 0.01% does not inhibit the spore germination and outgrowth in CF5 and M120 strains, but at a higher concentration of 0.1%, it significantly inhibits these processes. At a much lower concentration (0.00003%), it prevents the growth of CD196, M68, CF5, 630, and BI9 strains, while also substantially reducing toxin activity in CF5, BI9, M120, and 630 strains. Furthermore, a slightly higher concentration of Isolithocholic Acid (0.0003%) results in a significant decrease in toxin activity across all strains, with the exception of R20291 and M120[3].
In vivo	Fecal Isolithocholic Acid levels significantly decrease starting from day 28 in the high fat diet (HFD) group when compared to rats on a normal diet[4].

Synonyms	3-Epilithocholic acid, 3β-Hydroxy-5β-cholanic acid, β-Lithocholic acid, isoLCA
Molecular Weight	376.57
Formula	C24H40O3
CAS No.	1534-35-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform: Slightly soluble

Ethanol: Slightly soluble

Methanol: Slightly soluble

DMSO: 4.4 mg/mL (11.68 mM)

References and Literature

1. Batta, A.K., Salen, G., and Shefer, S.Transformation of bile acids into iso-bile acids by Clostridium perfringes: Possible transport of 3β-hydrogen via the coenzymeHepatology5(6)1126-1131(1985) 2. Borriello, S.P., and Owen, R.W.The metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacteriaLipids17(7)477-482(1982) 3. Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017) 4. Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)

Related compound libraries

This product is contained In the following compound libraries：

Human Metabolite Library Gut Microbial Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Isolithocholic Acid 1534-35-6 Metabolism Endogenous Metabolite beta-Lithocholic acid 3b-Hydroxy-5b-cholanic acid 3-Epilithocholic acid 3β-Hydroxy-5β-cholanic acid β-Lithocholic acid isoLCA b-Lithocholic acid 3beta-Hydroxy-5beta-cholanic acid inhibitor inhibit

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