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Fomivirsen sodium
(Synonyms: ISIS-2922 sodium, ISIS2922 sodium) Copy Product Info
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Synonyms: ISIS-2922 sodium, ISIS2922 sodium
Catalog No. T39068 Copy Product Info
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Fomivirsen sodium (ISIS-2922 sodium) is a 21-base phosphorothioate oligodeoxynucleotide that is complementary to the mRNA of the major immediate early region (IE2) of human cytomegalovirus (CMV). It inhibits viral replication by cleaving the target mRNA through the ribonuclease H (RNase H) mechanism. Following intravitreal administration, it can be used in research related to cytomegalovirus retinitis associated with AIDS.
Cas No. 160369-77-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $103 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Chemical Properties
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| Description | Fomivirsen sodium (ISIS-2922 sodium) is a 21-base phosphorothioate oligodeoxynucleotide that is complementary to the mRNA of the major immediate early region (IE2) of human cytomegalovirus (CMV). It inhibits viral replication by cleaving the target mRNA through the ribonuclease H (RNase H) mechanism. Following intravitreal administration, it can be used in research related to cytomegalovirus retinitis associated with AIDS. |
| Targets & IC50 | MRC5 cells:0.2 μM, RPE cells:0.03 μM |
| In vitro | Method: Human retinal pigment epithelial (RPE) cells and human fibroblast cells (MRC-5) were treated with fomivirsen. Inhibition of CMV replication was measured, and the IC50 was calculated. Result: Fomivirsen dose-dependently inhibited CMV replication in both RPE cells and MRC-5 cells. The mean IC50 was 0.03 μM in RPE cells and 0.2 μM in MRC-5 cells [1]. |
| In vivo | Method: A single intravitreal injection of 66 μg fomivirsen was administered into rabbit eyes. Vitreous clearance was measured, and the half-life was calculated following first-order kinetics. Result: The clearance half-life of fomivirsen from the vitreous in rabbit eyes was 62 hours. At day 10, 22% of the total radioactivity remained in the vitreous [1]. |
| Synonyms | ISIS-2922 sodium, ISIS2922 sodium |
| Cas No. | 160369-77-7 |
| Storage | Store under nitrogen, -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 80 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Fomivirsen sodium chemical structure | Fomivirsen sodium in vivo | Fomivirsen sodium in vitro
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