Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Fomivirsen sodium

Name: Fomivirsen sodium
Brand: TargetMol
SKU: T39068
Rating: 4.5 (1 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T39068 Copy Product Info

🥰Excellent

Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein (required for viral replication), thus providing bioactive effects for CMV retinitis by inhibition of virus proliferation.

Cas No. 160369-77-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

In vitro

The antisense oligonucleotide fomivirsen serves as a complementary sequence for the messenger RNA (mRNA) of major immediate-early proteins in human cytomegalovirus, thereby hindering the virus's replication via an antisense mechanism[1]. As a 21-mer phosphorothioate antisense oligonucleotide (ASO) featuring a CpG motif near its 5′ end (sequence: 5′-GCG TTT GCT CTT CTT CTT GCG-3′), fomivirsen leads to mRNA degradation through an RNase H-mediated process[2]. Demonstrated to suppress cytomegalovirus (CMV) replication in both human retinal pigment epithelial (RPE) cells and human fibroblast (MRC-5) cells in a concentration-dependent fashion, fomivirsen presents a mean inhibitory concentration (IC 50) of 0.03 μM for RPE cells and 0.2 μM for MRC-5 cells[1].

Chemical Properties

Cas No.

160369-77-7

Storage & Solubility Information

Storage

-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc